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Kifap3 kinesin-associated protein 3 [ Mus musculus (house mouse) ]

Gene ID: 16579, updated on 8-Feb-2024

Summary

Official Symbol
Kifap3provided by MGI
Official Full Name
kinesin-associated protein 3provided by MGI
Primary source
MGI:MGI:107566
See related
Ensembl:ENSMUSG00000026585 AllianceGenome:MGI:107566
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KAP3; SMAP; KAP-3
Summary
The protein encoded by this gene is the non-motor subunit of kinesin-2 complex, and forms a heterotrimer with two members of the kinesin superfamily of proteins that together form a microtubule plus-end directed translocator that plays an important role in intracellular transport, mitosis, and cell-cell adhesion. This protein contains multiple armadillo repeats involved in protein binding, and may serve as an adaptor to regulate binding of cargo with the motor proteins. Conditional disruption of this gene in mouse neural precursor cells caused a tumor-like phenotype and defective organization of the neuroepithelium thought to be the result of altered N-cadherin subcellular localization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Expression
Broad expression in CNS E18 (RPKM 36.2), cortex adult (RPKM 29.0) and 15 other tissues See more
Orthologs
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Genomic context

See Kifap3 in Genome Data Viewer
Location:
1 H2.1; 1 71.08 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (163589711..163744676)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (163762138..163917107)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02856 Neighboring gene STARR-seq mESC enhancer starr_02857 Neighboring gene N-terminal Xaa-Pro-Lys N-methyltransferase 2 Neighboring gene GC-rich promoter binding protein 1-like 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:165709472-165709665 Neighboring gene predicted gene, 51663 Neighboring gene STARR-seq mESC enhancer starr_02858 Neighboring gene STARR-seq mESC enhancer starr_02859 Neighboring gene SCY1-like 3 (S. cerevisiae) Neighboring gene FIGNL1 interacting regulator of recombination and mitosis Neighboring gene STARR-positive B cell enhancer ABC_E2015 Neighboring gene methyltransferase like 18

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables intraciliary transport particle B binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cilium organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule-based process IPI
Inferred from Physical Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of calcium-dependent cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin II complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of kinesin II complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin II complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of kinesin II complex ISO
Inferred from Sequence Orthology
more info
 
part_of kinesin complex IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in periciliary membrane compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor connecting cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with spindle microtubule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinesin-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305643.1NP_001292572.1  kinesin-associated protein 3 isoform KAP3A

    See identical proteins and their annotated locations for NP_001292572.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (KAP3A, PMID:8710890).
    Source sequence(s)
    AK013954, AK133957, BC040362, BU701040
    Consensus CDS
    CCDS78729.1
    UniProtKB/Swiss-Prot
    P70188, P70189, Q6GTS3
    UniProtKB/TrEMBL
    Q3UZA5
    Related
    ENSMUSP00000027877.6, ENSMUST00000027877.7
    Conserved Domains (2) summary
    cd00020
    Location:578662
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05804
    Location:13720
    KAP; Kinesin-associated protein (KAP)
  2. NM_010629.3NP_034759.1  kinesin-associated protein 3 isoform KAP3B

    See identical proteins and their annotated locations for NP_034759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region and differs in its 3' UTR, compared to variant 1. The encoded isoform (KAP3B, PMID:8710890) is shorter and has a distinct C-terminus, compared to KAP3A.
    Source sequence(s)
    AK013954, BC040362, BU701040
    Consensus CDS
    CCDS35751.1
    UniProtKB/TrEMBL
    Q3UZA5
    Related
    ENSMUSP00000076830.6, ENSMUST00000077642.12
    Conserved Domains (2) summary
    cd00020
    Location:578662
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05804
    Location:13720
    KAP; Kinesin-associated protein (KAP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    163589711..163744676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496681.4XP_006496744.1  kinesin-associated protein 3 isoform X2

    UniProtKB/TrEMBL
    Q3UZA5
    Conserved Domains (1) summary
    pfam05804
    Location:29736
    KAP; Kinesin-associated protein (KAP)
  2. XM_006496679.4XP_006496742.1  kinesin-associated protein 3 isoform X1

    UniProtKB/TrEMBL
    Q3UZA5
    Conserved Domains (1) summary
    pfam05804
    Location:29736
    KAP; Kinesin-associated protein (KAP)