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Mdfic MyoD family inhibitor domain containing [ Mus musculus (house mouse) ]

Gene ID: 16543, updated on 26-Sep-2022

Summary

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Official Symbol
Mdficprovided by MGI
Official Full Name
MyoD family inhibitor domain containingprovided by MGI
Primary source
MGI:MGI:104611
See related
Ensembl:ENSMUSG00000041390 AllianceGenome:MGI:104611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kdt1; Mdfid
Summary
This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, which in human have been shown to have different subcellular localization. [provided by RefSeq, Jul 2008]
Expression
Broad expression in ovary adult (RPKM 10.4), bladder adult (RPKM 8.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Mdfic in Genome Data Viewer
Location:
6; 6 A1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (15720660..15802168)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (15720566..15802169)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene forkhead box P2 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene predicted gene, 36352 Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 36406

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). Thompson HA, et al. Endocrinology, 1995 Jul. PMID 7789330
  2. Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV-1 expression. Thébault S, et al. J Biol Chem, 2000 Feb 18. PMID 10671520
  3. Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema. Byrne AB, et al. Sci Transl Med, 2022 Mar 2. PMID 35235341
  4. Nucleolar release of Hand1 acts as a molecular switch to determine cell fate. Martindill DM, et al. Nat Cell Biol, 2007 Oct. PMID 17891141
  5. Myogenic repressor I-mfa interferes with the function of Zic family proteins. Mizugishi K, et al. Biochem Biophys Res Commun, 2004 Jul 16. PMID 15207726

See all (20) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema.
    Title: Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables Tat protein binding ISO
Inferred from Sequence Orthology
more info
  
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of viral transcription IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of viral transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myoD family inhibitor domain-containing protein
Names
I-mfa domain-containing protein
kidney cell line-derived transcript 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175088.5 → NP_780297.3  myoD family inhibitor domain-containing protein

    See identical proteins and their annotated locations for NP_780297.3

    Status: REVIEWED

    Source sequence(s)
    AK087298, AK165016, BB603899, BG083307, BY509244, CO043232
    Consensus CDS
    CCDS19919.1
    UniProtKB/Swiss-Prot
    Q8BJS3, Q8BX65
    Related
    ENSMUSP00000140208.2, ENSMUST00000189359.7
    Conserved Domains (1) summary
    pfam15316
    Location:74 → 247
    MDFI; MyoD family inhibitor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    15720660..15802168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165885.1 → XP_036021778.1  myoD family inhibitor domain-containing protein isoform X1

    Conserved Domains (1) summary
    pfam15316
    Location:19 → 192
    MDFI; MyoD family inhibitor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BX65.1 GenPept UniProtKB/Swiss-Prot:Q8BX65

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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