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UBXN2A UBX domain protein 2A [ Homo sapiens (human) ]

Gene ID: 165324, updated on 5-Aug-2022

Summary

Official Symbol
UBXN2Aprovided by HGNC
Official Full Name
UBX domain protein 2Aprovided by HGNC
Primary source
HGNC:HGNC:27265
See related
Ensembl:ENSG00000173960 AllianceGenome:HGNC:27265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBXD4
Summary
Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including autophagosome assembly; nuclear membrane reassembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; regulation of gene expression; and regulation of protein metabolic process. Predicted to be located in cis-Golgi network and endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 3.2), esophagus (RPKM 2.9) and 25 other tissues See more
Orthologs
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Genomic context

See UBXN2A in Genome Data Viewer
Location:
2p23.3
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (23927278..24004909)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (23975156..24039606)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24163333..24227779)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATPase family AAA domain containing 2B Neighboring gene phosphoglycerate mutase 1 pseudogene 6 Neighboring gene ribosomal protein S13 pseudogene 4 Neighboring gene succinate dehydrogenase complex subunit C pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 610, pseudogene Neighboring gene Sharpr-MPRA regulatory region 11775 Neighboring gene MFSD2 lysolipid transporter B, sphingolipid Neighboring gene RNA, U6 small nuclear 370, pseudogene Neighboring gene FKBP prolyl isomerase 1B Neighboring gene WD repeat and coiled coil containing

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
EBI GWAS Catalog
Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138202

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acetylcholine receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear membrane reassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cis-Golgi network IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
UBX domain-containing protein 2A
Names
UBX domain containing 4
UBX domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181713.4NP_859064.2  UBX domain-containing protein 2A

    See identical proteins and their annotated locations for NP_859064.2

    Status: VALIDATED

    Source sequence(s)
    AC066692, AL832079, BC016364
    Consensus CDS
    CCDS1704.1
    UniProtKB/Swiss-Prot
    P68543, Q569G8
    Related
    ENSP00000312107.4, ENST00000309033.5
    Conserved Domains (2) summary
    cd17160
    Location:167250
    UBX_UBXN2A; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 2A (UBXN2A) and similar proteins
    pfam08059
    Location:65138
    SEP; SEP domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    23927278..24004909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264168.6XP_005264225.1  UBX domain-containing protein 2A isoform X1

    See identical proteins and their annotated locations for XP_005264225.1

    UniProtKB/Swiss-Prot
    P68543, Q569G8
    Conserved Domains (2) summary
    cd17160
    Location:167250
    UBX_UBXN2A; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 2A (UBXN2A) and similar proteins
    pfam08059
    Location:65138
    SEP; SEP domain
  2. XM_011532633.4XP_011530935.1  UBX domain-containing protein 2A isoform X1

    See identical proteins and their annotated locations for XP_011530935.1

    UniProtKB/Swiss-Prot
    P68543, Q569G8
    Related
    ENSP00000385525.1, ENST00000404924.5
    Conserved Domains (2) summary
    cd17160
    Location:167250
    UBX_UBXN2A; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 2A (UBXN2A) and similar proteins
    pfam08059
    Location:65138
    SEP; SEP domain
  3. XM_005264166.6XP_005264223.1  UBX domain-containing protein 2A isoform X1

    See identical proteins and their annotated locations for XP_005264223.1

    UniProtKB/Swiss-Prot
    P68543, Q569G8
    Conserved Domains (2) summary
    cd17160
    Location:167250
    UBX_UBXN2A; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 2A (UBXN2A) and similar proteins
    pfam08059
    Location:65138
    SEP; SEP domain
  4. XM_047443579.1XP_047299535.1  UBX domain-containing protein 2A isoform X1

    UniProtKB/Swiss-Prot
    Q569G8
  5. XM_017003517.3XP_016859006.1  UBX domain-containing protein 2A isoform X3

  6. XM_047443581.1XP_047299537.1  UBX domain-containing protein 2A isoform X2

  7. XM_005264169.5XP_005264226.1  UBX domain-containing protein 2A isoform X1

    See identical proteins and their annotated locations for XP_005264226.1

    UniProtKB/Swiss-Prot
    P68543, Q569G8
    Conserved Domains (2) summary
    cd17160
    Location:167250
    UBX_UBXN2A; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 2A (UBXN2A) and similar proteins
    pfam08059
    Location:65138
    SEP; SEP domain
  8. XM_005264167.6XP_005264224.1  UBX domain-containing protein 2A isoform X1

    See identical proteins and their annotated locations for XP_005264224.1

    UniProtKB/Swiss-Prot
    P68543, Q569G8
    Conserved Domains (2) summary
    cd17160
    Location:167250
    UBX_UBXN2A; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 2A (UBXN2A) and similar proteins
    pfam08059
    Location:65138
    SEP; SEP domain
  9. XM_047443580.1XP_047299536.1  UBX domain-containing protein 2A isoform X1

    UniProtKB/Swiss-Prot
    Q569G8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    23975156..24039606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)