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UBXN2A UBX domain protein 2A [ Homo sapiens (human) ]

Gene ID: 165324, updated on 20-Mar-2020

Summary

Official Symbol
UBXN2Aprovided by HGNC
Official Full Name
UBX domain protein 2Aprovided by HGNC
Primary source
HGNC:HGNC:27265
See related
Ensembl:ENSG00000173960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBXD4
Expression
Ubiquitous expression in fat (RPKM 3.2), esophagus (RPKM 2.9) and 25 other tissues See more
Orthologs

Genomic context

See UBXN2A in Genome Data Viewer
Location:
2p23.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (23927172..24004909)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24150132..24223701)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATPase family AAA domain containing 2B Neighboring gene phosphoglycerate mutase 1 pseudogene 6 Neighboring gene ribosomal protein S13 pseudogene 4 Neighboring gene succinate dehydrogenase complex subunit C pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 610, pseudogene Neighboring gene major facilitator superfamily domain containing 2B Neighboring gene RNA, U6 small nuclear 370, pseudogene Neighboring gene FKBP prolyl isomerase 1B Neighboring gene WD repeat and coiled coil containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
NHGRI GWA Catalog
Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138202

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetylcholine receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope reassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cis-Golgi network IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
UBX domain-containing protein 2A
Names
UBX domain containing 4
UBX domain-containing protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181713.4NP_859064.2  UBX domain-containing protein 2A

    See identical proteins and their annotated locations for NP_859064.2

    Status: VALIDATED

    Source sequence(s)
    AC066692, AL832079, BC016364
    Consensus CDS
    CCDS1704.1
    UniProtKB/Swiss-Prot
    P68543
    Related
    ENSP00000312107.4, ENST00000309033.5
    Conserved Domains (2) summary
    cd01770
    Location:170248
    p47_UBX; p47-like ubiquitin domain
    pfam08059
    Location:65138
    SEP; SEP domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    23927172..24004909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264168.5XP_005264225.1  UBX domain-containing protein 2A isoform X1

    See identical proteins and their annotated locations for XP_005264225.1

    UniProtKB/Swiss-Prot
    P68543
    Conserved Domains (2) summary
    cd01770
    Location:170248
    p47_UBX; p47-like ubiquitin domain
    pfam08059
    Location:65138
    SEP; SEP domain
  2. XM_011532633.3XP_011530935.1  UBX domain-containing protein 2A isoform X1

    See identical proteins and their annotated locations for XP_011530935.1

    UniProtKB/Swiss-Prot
    P68543
    Related
    ENSP00000385525.1, ENST00000404924.5
    Conserved Domains (2) summary
    cd01770
    Location:170248
    p47_UBX; p47-like ubiquitin domain
    pfam08059
    Location:65138
    SEP; SEP domain
  3. XM_005264166.5XP_005264223.1  UBX domain-containing protein 2A isoform X1

    See identical proteins and their annotated locations for XP_005264223.1

    UniProtKB/Swiss-Prot
    P68543
    Related
    ENST00000446425.2
    Conserved Domains (2) summary
    cd01770
    Location:170248
    p47_UBX; p47-like ubiquitin domain
    pfam08059
    Location:65138
    SEP; SEP domain
  4. XM_024452738.1XP_024308506.1  UBX domain-containing protein 2A isoform X3

    Conserved Domains (2) summary
    cd01770
    Location:111189
    p47_UBX; p47-like ubiquitin domain
    pfam08059
    Location:679
    SEP; SEP domain
  5. XM_017003517.2XP_016859006.1  UBX domain-containing protein 2A isoform X2

  6. XM_017003518.1XP_016859007.1  UBX domain-containing protein 2A isoform X3

    Conserved Domains (2) summary
    cd01770
    Location:111189
    p47_UBX; p47-like ubiquitin domain
    pfam08059
    Location:679
    SEP; SEP domain
  7. XM_005264169.4XP_005264226.1  UBX domain-containing protein 2A isoform X1

    See identical proteins and their annotated locations for XP_005264226.1

    UniProtKB/Swiss-Prot
    P68543
    Conserved Domains (2) summary
    cd01770
    Location:170248
    p47_UBX; p47-like ubiquitin domain
    pfam08059
    Location:65138
    SEP; SEP domain
  8. XM_005264167.5XP_005264224.1  UBX domain-containing protein 2A isoform X1

    See identical proteins and their annotated locations for XP_005264224.1

    UniProtKB/Swiss-Prot
    P68543
    Conserved Domains (2) summary
    cd01770
    Location:170248
    p47_UBX; p47-like ubiquitin domain
    pfam08059
    Location:65138
    SEP; SEP domain
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