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CCDC138 coiled-coil domain containing 138 [ Homo sapiens (human) ]

Gene ID: 165055, updated on 4-Jul-2021

Summary

Official Symbol
CCDC138provided by HGNC
Official Full Name
coiled-coil domain containing 138provided by HGNC
Primary source
HGNC:HGNC:26531
See related
Ensembl:ENSG00000163006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 1.8), lymph node (RPKM 0.7) and 23 other tissues See more
Orthologs
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Genomic context

See CCDC138 in Genome Data Viewer
Location:
2q13
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (108786733..108885485)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (109403206..109501941)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10 pseudogene 5 Neighboring gene RAN binding protein 2 Neighboring gene ribosomal protein L39 pseudogene 16 Neighboring gene ectodysplasin A receptor Neighboring gene SH3RF3 antisense RNA 1 Neighboring gene SH3 domain containing ring finger 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32745

General protein information

Preferred Names
coiled-coil domain-containing protein 138

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303105.2NP_001290034.1  coiled-coil domain-containing protein 138 isoform 2

    See identical proteins and their annotated locations for NP_001290034.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC010095, AC073415
    Consensus CDS
    CCDS77447.1
    UniProtKB/Swiss-Prot
    Q96M89
    Related
    ENSP00000411800.2, ENST00000412964.6
    Conserved Domains (2) summary
    pfam12718
    Location:213320
    Tropomyosin_1; Tropomyosin like
    cl19511
    Location:212315
    DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
  2. NM_001303106.2NP_001290035.1  coiled-coil domain-containing protein 138 isoform 3

    See identical proteins and their annotated locations for NP_001290035.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in its 5' UTR which results in the use of a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to variant 1. Variants 3 and 16 both encode the same isoform (3).
    Source sequence(s)
    AC010095, AC073415
  3. NM_001351544.2NP_001338473.1  coiled-coil domain-containing protein 138 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (4).
    Source sequence(s)
    AC010095, AC073415
    Conserved Domains (1) summary
    cl25732
    Location:169346
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_001351545.1NP_001338474.1  coiled-coil domain-containing protein 138 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC010095, AC073415, BG216415, BQ007723
    Conserved Domains (1) summary
    cl25732
    Location:158335
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_001351548.1NP_001338477.1  coiled-coil domain-containing protein 138 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC010095, AC073415, BG216415, BQ007723
    Conserved Domains (1) summary
    cl25732
    Location:121298
    SMC_N; RecF/RecN/SMC N terminal domain
  6. NM_001351549.2NP_001338478.1  coiled-coil domain-containing protein 138 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC010095, AC073415
    Conserved Domains (1) summary
    cl25732
    Location:163340
    SMC_N; RecF/RecN/SMC N terminal domain
  7. NM_001351551.2NP_001338480.1  coiled-coil domain-containing protein 138 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC010095, AC073415
    Conserved Domains (1) summary
    cl25732
    Location:164320
    SMC_N; RecF/RecN/SMC N terminal domain
  8. NM_001351553.2NP_001338482.1  coiled-coil domain-containing protein 138 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC010095, AC073415
    Conserved Domains (1) summary
    cl25732
    Location:169346
    SMC_N; RecF/RecN/SMC N terminal domain
  9. NM_001351554.2NP_001338483.1  coiled-coil domain-containing protein 138 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC010095, AC073415
    Conserved Domains (1) summary
    cl25732
    Location:170326
    SMC_N; RecF/RecN/SMC N terminal domain
  10. NM_001351555.2NP_001338484.1  coiled-coil domain-containing protein 138 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC010095, AC073415
    Conserved Domains (1) summary
    cl25732
    Location:164320
    SMC_N; RecF/RecN/SMC N terminal domain
  11. NM_001351557.1NP_001338486.1  coiled-coil domain-containing protein 138 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC010095, AC073415
    Conserved Domains (2) summary
    cl19252
    Location:208464
    MreC; rod shape-determining protein MreC
    cl25732
    Location:158335
    SMC_N; RecF/RecN/SMC N terminal domain
  12. NM_001351559.2NP_001338488.1  coiled-coil domain-containing protein 138 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC010095, AC073415
    Conserved Domains (1) summary
    cl25732
    Location:163340
    SMC_N; RecF/RecN/SMC N terminal domain
  13. NM_001351561.1NP_001338490.1  coiled-coil domain-containing protein 138 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC010095, AC073415, BG216415, BQ007723
    Conserved Domains (1) summary
    cl25732
    Location:158335
    SMC_N; RecF/RecN/SMC N terminal domain
  14. NM_001351565.2NP_001338494.1  coiled-coil domain-containing protein 138 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AC010095, AC073415
  15. NM_144978.3NP_659415.1  coiled-coil domain-containing protein 138 isoform 1

    See identical proteins and their annotated locations for NP_659415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC010095, AC073415
    Consensus CDS
    CCDS2080.1
    UniProtKB/Swiss-Prot
    Q96M89
    Related
    ENSP00000295124.4, ENST00000295124.9
    Conserved Domains (2) summary
    pfam12718
    Location:213320
    Tropomyosin_1; Tropomyosin like
    cl19511
    Location:212315
    DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)

RNA

  1. NR_130121.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in an internal exon and lacks an internal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC010095, AC073415
    Related
    ENST00000409529.6
  2. NR_147236.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010095, AC073415
  3. NR_147237.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010095, AC073415
  4. NR_147238.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010095, AC073415

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    108786733..108885485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452737.1XP_024308505.1  coiled-coil domain-containing protein 138 isoform X9

    Conserved Domains (2) summary
    cl19252
    Location:208464
    MreC; rod shape-determining protein MreC
    cl25732
    Location:158335
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_017003493.2XP_016858982.1  coiled-coil domain-containing protein 138 isoform X4

  3. XM_017003503.1XP_016858992.1  coiled-coil domain-containing protein 138 isoform X8

  4. XM_017003492.1XP_016858981.1  coiled-coil domain-containing protein 138 isoform X2

  5. XM_011510761.2XP_011509063.1  coiled-coil domain-containing protein 138 isoform X5

    Conserved Domains (2) summary
    pfam12718
    Location:219326
    Tropomyosin_1; Tropomyosin like
    cl19511
    Location:218321
    DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
  6. XM_017003498.1XP_016858987.1  coiled-coil domain-containing protein 138 isoform X6

  7. XM_011510760.2XP_011509062.1  coiled-coil domain-containing protein 138 isoform X3

    Conserved Domains (3) summary
    pfam12718
    Location:219326
    Tropomyosin_1; Tropomyosin like
    cl19252
    Location:256475
    MreC; rod shape-determining protein MreC
    cl19511
    Location:218321
    DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
  8. XM_011510762.2XP_011509064.1  coiled-coil domain-containing protein 138 isoform X7

    Conserved Domains (2) summary
    pfam12718
    Location:219326
    Tropomyosin_1; Tropomyosin like
    cl19252
    Location:219365
    MreC; rod shape-determining protein MreC
  9. XM_011510757.2XP_011509059.1  coiled-coil domain-containing protein 138 isoform X1

    Conserved Domains (2) summary
    pfam12718
    Location:219325
    Tropomyosin_1; Tropomyosin like
    cl19252
    Location:235364
    MreC; rod shape-determining protein MreC
  10. XM_017003504.1XP_016858993.1  coiled-coil domain-containing protein 138 isoform X8

  11. XM_017003502.1XP_016858991.1  coiled-coil domain-containing protein 138 isoform X8

RNA

  1. XR_001738653.1 RNA Sequence

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