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Itpr3 inositol 1,4,5-triphosphate receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 16440, updated on 14-May-2024

Summary

Official Symbol
Itpr3provided by MGI
Official Full Name
inositol 1,4,5-triphosphate receptor 3provided by MGI
Primary source
MGI:MGI:96624
See related
Ensembl:ENSMUSG00000042644 AllianceGenome:MGI:96624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tf; Ip3r3; IP3R 3; Itpr-3
Summary
Enables inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity and phosphatidylinositol binding activity. Involved in calcium ion transport into cytosol. Acts upstream of or within several processes, including long-term synaptic potentiation; memory; and sensory perception of taste. Located in endoplasmic reticulum membrane; nucleolus; and nucleoplasm. Is expressed in several structures, including jaw; liver; sensory organ; skeleton; and spleen. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 33.0), spleen adult (RPKM 27.9) and 17 other tissues See more
Orthologs
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Genomic context

See Itpr3 in Genome Data Viewer
Location:
17 A3.3; 17 13.68 cM
Exon count:
58
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27275976..27341197)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27057002..27122223)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7502 Neighboring gene zinc finger and BTB domain containing 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27137073-27137182 Neighboring gene STARR-positive B cell enhancer ABC_E11633 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27164461-27164644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27165231-27165340 Neighboring gene gametogenetin binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_42142 Neighboring gene BCL2-antagonist/killer 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27193173-27193441 Neighboring gene microRNA 7677 Neighboring gene inositol 1,4,5-triphosphate receptor 3, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E1191 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 2 Neighboring gene inositol hexaphosphate kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
tufted
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables inositol 1,3,4,5 tetrakisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol 1,4,5 trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables inositol 1,4,5-trisphosphate-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables inositol hexakisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables intracellularly gated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of bitter taste IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of sweet taste IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of umami taste IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in sarcoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in secretory granule membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
inositol 1,4,5-trisphosphate receptor type 3
Names
IP3 receptor
insP3R3
type 3 InsP3 receptor
type 3 inositol 1,4,5-trisphosphate receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080553.3NP_542120.2  inositol 1,4,5-trisphosphate receptor type 3

    See identical proteins and their annotated locations for NP_542120.2

    Status: VALIDATED

    Source sequence(s)
    AB182289, BB866373, BP754037
    Consensus CDS
    CCDS28560.1
    UniProtKB/Swiss-Prot
    P70227, Q5DWM4, Q8CED5, Q91Z08
    Related
    ENSMUSP00000038150.9, ENSMUST00000049308.9
    Conserved Domains (7) summary
    smart00472
    Location:232288
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    pfam00520
    Location:22732527
    Ion_trans; Ion transport protein
    pfam01365
    Location:475665
    RYDR_ITPR; RIH domain
    pfam02815
    Location:234432
    MIR; MIR domain
    pfam08454
    Location:18681973
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:3226
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    pfam12730
    Location:22002331
    ABC2_membrane_4; ABC-2 family transporter protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    27275976..27341197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523712.4XP_006523775.1  inositol 1,4,5-trisphosphate receptor type 3 isoform X1

    Conserved Domains (5) summary
    pfam00520
    Location:23902654
    Ion_trans; Ion transport protein
    pfam01365
    Location:574771
    RYDR_ITPR; RIH domain
    pfam02815
    Location:335533
    MIR; MIR domain
    pfam08454
    Location:19952100
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:104327
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  2. XM_036160338.1XP_036016231.1  inositol 1,4,5-trisphosphate receptor type 3 isoform X2

    Conserved Domains (3) summary
    pfam00520
    Location:12611524
    Ion_trans; Ion transport protein
    pfam01365
    Location:188300
    RYDR_ITPR; RIH domain
    pfam08454
    Location:861970
    RIH_assoc; RyR and IP3R Homology associated