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Itpr1 inositol 1,4,5-trisphosphate receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 16438, updated on 8-Jan-2023

Summary

Official Symbol
Itpr1provided by MGI
Official Full Name
inositol 1,4,5-trisphosphate receptor 1provided by MGI
Primary source
MGI:MGI:96623
See related
Ensembl:ENSMUSG00000030102 AllianceGenome:MGI:96623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
opt; Ip3r; P400; Pcp1; wblo; IP3R1; Pcp-1; D6Pas2; IP3R 1; InsP3R; Itpr-1; Gm10429; insP3R1
Summary
Enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels; phosphatidylinositol binding activity; and protein domain specific binding activity. Involved in several processes, including epithelial fluid transport; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including calcium ion transport; endoplasmic reticulum calcium ion homeostasis; and voluntary musculoskeletal movement. Located in endoplasmic reticulum; nucleus; and postsynaptic density. Part of calcineurin complex. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including brain; brown fat; genitourinary system; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in Gillespie syndrome; spinocerebellar ataxia type 15; and spinocerebellar ataxia type 29. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 104.2), cortex adult (RPKM 29.7) and 9 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See Itpr1 in Genome Data Viewer
Location:
6 E1- E2; 6 49.74 cM
Exon count:
65
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (108190044..108528077)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (108213083..108551116)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36, pseudogene 12 Neighboring gene sulfatase modifying factor 1 Neighboring gene predicted gene, 38872 Neighboring gene predicted gene, 35165 Neighboring gene microRNA 7661 Neighboring gene predicted gene, 44040 Neighboring gene RIKEN cDNA 0610040F04 gene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene basic helix-loop-helix family, member e40

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels EXP
Inferred from Experiment
more info
PubMed 
enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels IDA
Inferred from Direct Assay
more info
PubMed 
enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
enables inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity TAS
Traceable Author Statement
more info
PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in epithelial fluid transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within inositol phosphate-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ion channel modulating, G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ion channel modulating, G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ligand-gated ion channel signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ligand-gated ion channel signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in liver regeneration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of postsynaptic cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within voluntary musculoskeletal movement IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in Schaffer collateral - CA1 synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of calcineurin complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in platelet dense granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in platelet dense tubular network ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in sarcoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in secretory granule membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in smooth endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IPI
Inferred from Physical Interaction
more info
PubMed 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
inositol 1,4,5-trisphosphate receptor type 1
Names
IP3 receptor
InsP>3<R type I
Purkinje cell protein 1
inositol 1,4,5-trisphosphate-binding protein P400
opisthotonus
protein PCD-6
type 1 InsP3 receptor
type 1 inositol 1,4,5-trisphosphate receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010585.5NP_034715.3  inositol 1,4,5-trisphosphate receptor type 1

    See identical proteins and their annotated locations for NP_034715.3

    Status: VALIDATED

    Source sequence(s)
    AC156506, AK044776, AK047719, AK049015, AK137477, BU705754, CB521690, CF168791, CF539692, CF744794, CJ236273, CK636937, CN459019, CN692248, DN176734, DV652411, M21530
    Consensus CDS
    CCDS51869.1
    UniProtKB/Swiss-Prot
    P11881, Q99LG5
    UniProtKB/TrEMBL
    Q3UVA1, Q8BQN0, Q8C7X9, Q8C8N0
    Related
    ENSMUSP00000032192.7, ENSMUST00000032192.9
    Conserved Domains (6) summary
    smart00472
    Location:231287
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    pfam00520
    Location:23412600
    Ion_trans; Ion transport protein
    pfam01365
    Location:476665
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232433
    MIR; MIR domain
    pfam08454
    Location:19642069
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    108190044..108528077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505623.1XP_006505686.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X1

    Conserved Domains (5) summary
    pfam00520
    Location:23222609
    Ion_trans; Ion transport protein
    pfam01365
    Location:474670
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232433
    MIR; MIR domain
    pfam08454
    Location:19732078
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  2. XM_017321407.1XP_017176896.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X2

    Conserved Domains (5) summary
    pfam00520
    Location:23212608
    Ion_trans; Ion transport protein
    pfam01365
    Location:474670
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232433
    MIR; MIR domain
    pfam08454
    Location:19722077
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  3. XM_006505627.1XP_006505690.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X6

    Conserved Domains (5) summary
    pfam00520
    Location:23052592
    Ion_trans; Ion transport protein
    pfam01365
    Location:474670
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232433
    MIR; MIR domain
    pfam08454
    Location:19562061
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  4. XM_006505624.1XP_006505687.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X3

    Conserved Domains (5) summary
    pfam00520
    Location:23112598
    Ion_trans; Ion transport protein
    pfam01365
    Location:474670
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232433
    MIR; MIR domain
    pfam08454
    Location:19622067
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  5. XM_006505625.1XP_006505688.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X4

    Conserved Domains (5) summary
    pfam00520
    Location:23102597
    Ion_trans; Ion transport protein
    pfam01365
    Location:474670
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232433
    MIR; MIR domain
    pfam08454
    Location:19612066
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  6. XM_006505632.1XP_006505695.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X11

    Conserved Domains (5) summary
    pfam00520
    Location:22942581
    Ion_trans; Ion transport protein
    pfam01365
    Location:474670
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232433
    MIR; MIR domain
    pfam08454
    Location:19452050
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  7. XM_006505628.1XP_006505691.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X7

    Conserved Domains (5) summary
    pfam00520
    Location:22992586
    Ion_trans; Ion transport protein
    pfam01365
    Location:474670
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232433
    MIR; MIR domain
    pfam08454
    Location:19502055
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  8. XM_006505629.1XP_006505692.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X8

    Conserved Domains (5) summary
    pfam00520
    Location:22982585
    Ion_trans; Ion transport protein
    pfam01365
    Location:474670
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232433
    MIR; MIR domain
    pfam08454
    Location:19492054
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  9. XM_006505633.1XP_006505696.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X12

    Conserved Domains (5) summary
    pfam00520
    Location:22822569
    Ion_trans; Ion transport protein
    pfam01365
    Location:474670
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232433
    MIR; MIR domain
    pfam08454
    Location:19332038
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  10. XM_017321408.1XP_017176897.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X15

    UniProtKB/Swiss-Prot
    P11881
    Related
    ENSMUSP00000144880.2, ENSMUST00000203615.3
    Conserved Domains (5) summary
    pfam00520
    Location:23122599
    Ion_trans; Ion transport protein
    pfam01365
    Location:474670
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232433
    MIR; MIR domain
    pfam08454
    Location:19632068
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  11. XM_006505636.1XP_006505699.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X18

    UniProtKB/Swiss-Prot
    P11881
    Conserved Domains (5) summary
    pfam00520
    Location:22732560
    Ion_trans; Ion transport protein
    pfam01365
    Location:474670
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232433
    MIR; MIR domain
    pfam08454
    Location:19242029
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  12. XM_006505626.1XP_006505689.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X5

    Conserved Domains (5) summary
    pfam00520
    Location:23072594
    Ion_trans; Ion transport protein
    pfam01365
    Location:459655
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232418
    MIR; MIR domain
    pfam08454
    Location:19582063
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  13. XM_017321409.1XP_017176898.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X16

    Conserved Domains (5) summary
    pfam00520
    Location:23062593
    Ion_trans; Ion transport protein
    pfam01365
    Location:459655
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232418
    MIR; MIR domain
    pfam08454
    Location:19572062
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  14. XM_006505630.1XP_006505693.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X9

    UniProtKB/Swiss-Prot
    P11881
    Conserved Domains (5) summary
    pfam00520
    Location:22982585
    Ion_trans; Ion transport protein
    pfam01365
    Location:459655
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232418
    MIR; MIR domain
    pfam08454
    Location:19492054
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  15. XM_017321410.1XP_017176899.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X17

    UniProtKB/Swiss-Prot
    P11881
    Conserved Domains (5) summary
    pfam00520
    Location:22972584
    Ion_trans; Ion transport protein
    pfam01365
    Location:459655
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232418
    MIR; MIR domain
    pfam08454
    Location:19482053
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  16. XM_006505637.1XP_006505700.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X19

    UniProtKB/Swiss-Prot
    P11881
    Conserved Domains (5) summary
    pfam00520
    Location:22582545
    Ion_trans; Ion transport protein
    pfam01365
    Location:459655
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232418
    MIR; MIR domain
    pfam08454
    Location:19092014
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  17. XM_006505631.3XP_006505694.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X10

    Conserved Domains (5) summary
    pfam00520
    Location:23222609
    Ion_trans; Ion transport protein
    pfam01365
    Location:474670
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232433
    MIR; MIR domain
    pfam08454
    Location:19732078
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  18. XM_036165883.1XP_036021776.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X14

  19. XM_030255199.1XP_030111059.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X13

    Conserved Domains (5) summary
    pfam00520
    Location:22602547
    Ion_trans; Ion transport protein
    pfam01365
    Location:412608
    RYDR_ITPR; RIH domain
    pfam02815
    Location:170371
    MIR; MIR domain
    pfam08454
    Location:19112016
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:1163
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor