Format

Send to:

Choose Destination

APCDD1L APC down-regulated 1 like [ Homo sapiens (human) ]

Gene ID: 164284, updated on 11-Jun-2021

Summary

Official Symbol
APCDD1Lprovided by HGNC
Official Full Name
APC down-regulated 1 likeprovided by HGNC
Primary source
HGNC:HGNC:26892
See related
Ensembl:ENSG00000198768
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in salivary gland (RPKM 5.3), kidney (RPKM 1.7) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See APCDD1L in Genome Data Viewer
Location:
20q13.32
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (58459101..58515399, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (57034157..57090455, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RAB22A, member RAS oncogene family Neighboring gene VAMP associated protein B and C Neighboring gene APCDD1L divergent transcript Neighboring gene Sharpr-MPRA regulatory region 4326 Neighboring gene long intergenic non-protein coding RNA 1711

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90166, MGC126807, MGC126809

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein APCDD1-like
Names
adenomatosis polyposis coli down-regulated 1 like

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304787.2NP_001291716.1  protein APCDD1-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AK074647, AK293299, AL118513, BQ018966, DA665037
    UniProtKB/Swiss-Prot
    Q8NCL9
    UniProtKB/TrEMBL
    B4DDQ9
    Conserved Domains (1) summary
    pfam14921
    Location:48274
    APCDDC; Adenomatosis polyposis coli down-regulated 1
  2. NM_153360.3NP_699191.1  protein APCDD1-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_699191.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK074647, AL118513, BQ018966, DA665037
    Consensus CDS
    CCDS13467.1
    UniProtKB/Swiss-Prot
    Q8NCL9
    Related
    ENSP00000360191.3, ENST00000371149.8
    Conserved Domains (1) summary
    pfam14921
    Location:37263
    APCDDC; Adenomatosis polyposis coli down-regulated 1

RNA

  1. NR_130908.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons and its 3' terminal exon extends past a splice site used in variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL118513

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    58459101..58515399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center