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Itih3 inter-alpha trypsin inhibitor, heavy chain 3 [ Mus musculus (house mouse) ]

Gene ID: 16426, updated on 2-Nov-2024

Summary

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Official Symbol
Itih3provided by MGI
Official Full Name
inter-alpha trypsin inhibitor, heavy chain 3provided by MGI
Primary source
MGI:MGI:96620
See related
Ensembl:ENSMUSG00000006522 AllianceGenome:MGI:96620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Intin3; Itih-3; ITI-HC3
Summary
This gene encodes one of the heavy subunits of inter alpha trypsin inhibitor that functions as a protease inhibitor circulating in the plasma. The encoded protein undergoes proteolytic processing to generate a mature glycoprotein that is linked to the other subunits via an ester bond between the C-terminal aspartic acid residue and the N-acetyl galactosamine residue of chondroitin sulfate. This gene is located in a cluster of related inter alpha trypsin inhibitor genes on chromosome 14. [provided by RefSeq, Oct 2015]
Expression
Biased expression in liver E18 (RPKM 638.5), liver adult (RPKM 152.5) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Itih3 in Genome Data Viewer
Location:
14 B; 14 19.09 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30630529..30645748, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30908572..30923787, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene musculoskeletal, embryonic nuclear protein 1 Neighboring gene inter alpha-trypsin inhibitor, heavy chain 4 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E3106 Neighboring gene predicted gene, 41121

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury. Wu H, et al. Brain Res Bull, 2024 Jun 15. PMID 38641154
  2. The three heavy-chain precursors for the inter-alpha-inhibitor family in mouse: new members of the multicopper oxidase protein group with differential transcription in liver and brain. Chan P, et al. Biochem J, 1995 Mar 1. PMID 7534067, Free PMC Article
  3. Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes. Diarra-Mehrpour M, et al. Biochim Biophys Acta, 1994 Oct 18. PMID 7522574
  4. Comparative assignments of the genes of the inter-alpha-inhibitor family in human and mouse: ITIH4 is close to ITIH1 and ITIH3, on HSA 3 and MMU 14. Jean L, et al. Genomics, 1997 Apr 1. PMID 9126497
  5. The genes for the inter-alpha-inhibitor family share a homologous organization in human and mouse. Salier JP, et al. Mamm Genome, 1992. PMID 1371941

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury.
    Title: MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inter-alpha-trypsin inhibitor heavy chain H3
Names
ITI heavy chain H3
inter-alpha-inhibitor H3 chain
inter-alpha-inhibitor heavy chain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424470.1 → NP_001411399.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform 2 preproprotein

    Status: REVIEWED

    Source sequence(s)
    CT025528

  2. NM_001424471.1 → NP_001411400.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform 3 preproprotein

    Status: REVIEWED

    Source sequence(s)
    CT025528

  3. NM_008407.3 → NP_032433.2  inter-alpha-trypsin inhibitor heavy chain H3 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_032433.2

    Status: REVIEWED

    Source sequence(s)
    CT025528
    Consensus CDS
    CCDS49434.1
    UniProtKB/Swiss-Prot
    E9QME9, Q61704, Q91WG9
    Related
    ENSMUSP00000006697.9, ENSMUST00000006697.17
    Conserved Domains (4) summary
    smart00609
    Location:29 → 158
    VIT; Vault protein Inter-alpha-Trypsin domain
    TIGR03788
    Location:47 → 602
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam06668
    Location:683 → 870
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    cl00057
    Location:281 → 462
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30630529..30645748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518585.3 → XP_006518648.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform X1

    Conserved Domains (3) summary
    smart00609
    Location:29 → 158
    VIT; Vault protein Inter-alpha-Trypsin domain
    pfam06668
    Location:697 → 885
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    cl00057
    Location:281 → 462
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. XM_036158480.1 → XP_036014373.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform X5

    Conserved Domains (2) summary
    pfam06668
    Location:529 → 717
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    cl00057
    Location:113 → 294
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_006518588.1 → XP_006518651.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform X4

    Conserved Domains (3) summary
    smart00609
    Location:15 → 142
    VIT; Vault protein Inter-alpha-Trypsin domain
    pfam06668
    Location:681 → 869
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    cl00057
    Location:265 → 446
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RNA

  1. XR_003950825.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61704.3 GenPept UniProtKB/Swiss-Prot:Q61704

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