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Itga2 integrin alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 16398, updated on 11-Apr-2024

Summary

Official Symbol
Itga2provided by MGI
Official Full Name
integrin alpha 2provided by MGI
Primary source
MGI:MGI:96600
See related
Ensembl:ENSMUSG00000015533 AllianceGenome:MGI:96600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DX5; GPIa; CD49B
Summary
Enables amyloid-beta binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell migration; and positive regulation of cellular component organization. Predicted to act upstream of or within cell adhesion. Located in basal part of cell and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); and von Willebrand's disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 1.3), placenta adult (RPKM 1.3) and 21 other tissues See more
Orthologs
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Genomic context

See Itga2 in Genome Data Viewer
Location:
13 D2.2; 13 64.61 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (114969617..115068588, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (114833081..114932100, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53802 Neighboring gene predicted gene, 34790 Neighboring gene STARR-seq mESC enhancer starr_35767 Neighboring gene STARR-positive B cell enhancer ABC_E5421 Neighboring gene STARR-positive B cell enhancer mm9_chr13:115621672-115621973 Neighboring gene STARR-seq mESC enhancer starr_35768 Neighboring gene molybdenum cofactor synthesis 2 Neighboring gene predicted gene, 34845 Neighboring gene integrin alpha 1 Neighboring gene STARR-seq mESC enhancer starr_35769 Neighboring gene predicted gene 10734 Neighboring gene pelota mRNA surveillance and ribosome rescue factor Neighboring gene predicted gene, 41075 Neighboring gene predicted gene, 25985

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables collagen binding involved in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
enables collagen receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables laminin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in collagen-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of mechanical stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in hypotonic response ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell projection organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
involved_in skin morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in substrate-dependent cell migration ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in basal part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alpha2-beta1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
integrin alpha-2
Names
CD49 antigen-like family member B
VLA-2 receptor, alpha 2 subunit
collagen receptor
platelet membrane glycoprotein Ia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008396.4NP_032422.2  integrin alpha-2 precursor

    See identical proteins and their annotated locations for NP_032422.2

    Status: VALIDATED

    Source sequence(s)
    CT025598
    Consensus CDS
    CCDS26787.1
    UniProtKB/Swiss-Prot
    Q62163, Q62469, Q6P1C7
    Related
    ENSMUSP00000053891.9, ENSMUST00000056117.10
    Conserved Domains (4) summary
    smart00191
    Location:548601
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:170350
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11521166
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6461057
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    114969617..115068588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)