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KANK4 KN motif and ankyrin repeat domains 4 [ Homo sapiens (human) ]

Gene ID: 163782, updated on 7-Jun-2020

Summary

Official Symbol
KANK4provided by HGNC
Official Full Name
KN motif and ankyrin repeat domains 4provided by HGNC
Primary source
HGNC:HGNC:27263
See related
Ensembl:ENSG00000132854 MIM:614612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANKRD38; dJ1078M7.1
Expression
Biased expression in fat (RPKM 7.4), placenta (RPKM 5.9) and 10 other tissues See more
Orthologs

Genomic context

See KANK4 in Genome Data Viewer
Location:
1p31.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (62236165..62319434, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (62701837..62785083, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15a pseudogene 7 Neighboring gene LINE1 type transposase domain containing 1 Neighboring gene RNA, U6 small nuclear 371, pseudogene Neighboring gene uncharacterized LOC105378768 Neighboring gene ubiquitin specific peptidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10884, KIAA0172

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
KN motif and ankyrin repeat domain-containing protein 4
Names
ankyrin repeat domain 38
ankyrin repeat domain-containing protein 38
kidney ankyrin repeat-containing protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320269.2NP_001307198.1  KN motif and ankyrin repeat domain-containing protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (2) lacks an internal segment and is shorter compared to isoform 1.
    Source sequence(s)
    AK091941, AL139343, AL162739, BU738703, CB989254, CN314410
    Consensus CDS
    CCDS81334.1
    UniProtKB/Swiss-Prot
    Q5T7N3
    Related
    ENSP00000346352.3, ENST00000354381.3
    Conserved Domains (4) summary
    cd00204
    Location:190321
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:200298
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:287342
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:195227
    ANK; ANK repeat [structural motif]
  2. NM_181712.5NP_859063.3  KN motif and ankyrin repeat domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_859063.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL139343, AL162739, BC060866
    Consensus CDS
    CCDS620.1
    UniProtKB/Swiss-Prot
    Q5T7N3
    Related
    ENSP00000360195.4, ENST00000371153.9
    Conserved Domains (6) summary
    cd00204
    Location:818949
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06005
    Location:342387
    DUF904; Protein of unknown function (DUF904)
    pfam12075
    Location:2462
    KN_motif; KN motif
    pfam12796
    Location:828926
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:915970
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:823855
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    62236165..62319434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540845.3XP_011539147.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X2

    Conserved Domains (6) summary
    cd00204
    Location:818959
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12075
    Location:2462
    KN_motif; KN motif
    pfam12796
    Location:828929
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:905959
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:823869
    ANK; ANK repeat [structural motif]
    cl23720
    Location:341404
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. XM_017000483.2XP_016855972.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X3

  3. XM_017000484.2XP_016855973.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X4

    UniProtKB/Swiss-Prot
    Q5T7N3
    Conserved Domains (4) summary
    cd00204
    Location:190321
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:200298
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:287342
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:195227
    ANK; ANK repeat [structural motif]
  4. XM_011540843.3XP_011539145.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011539145.1

    UniProtKB/Swiss-Prot
    Q5T7N3
    Conserved Domains (6) summary
    cd00204
    Location:818949
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06005
    Location:342387
    DUF904; Protein of unknown function (DUF904)
    pfam12075
    Location:2462
    KN_motif; KN motif
    pfam12796
    Location:828926
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:915970
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:823855
    ANK; ANK repeat [structural motif]
  5. XM_017000485.2XP_016855974.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X5

    UniProtKB/TrEMBL
    B1ALP6
    Related
    ENSP00000360192.1, ENST00000371150.5
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