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TDRD5 tudor domain containing 5 [ Homo sapiens (human) ]

Gene ID: 163589, updated on 11-Jun-2021

Summary

Official Symbol
TDRD5provided by HGNC
Official Full Name
tudor domain containing 5provided by HGNC
Primary source
HGNC:HGNC:20614
See related
Ensembl:ENSG00000162782 MIM:617748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TUDOR3
Expression
Restricted expression toward testis (RPKM 11.6) See more
Orthologs
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Genomic context

See TDRD5 in Genome Data Viewer
Location:
1q25.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (179591613..179691272)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (179560748..179660407)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U5F small nuclear 2, pseudogene Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 pseudogene Neighboring gene uncharacterized LOC105371635 Neighboring gene family with sequence similarity 163 member A Neighboring gene uncharacterized LOC105371634 Neighboring gene microRNA 12116

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34823, MGC163404

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in DNA methylation involved in gamete generation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in P granule organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromatoid body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in pi-body ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tudor domain-containing protein 5
Names
testicular tissue protein Li 194

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053092.1 RefSeqGene

    Range
    5220..104660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199085.3NP_001186014.1  tudor domain-containing protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001186014.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 2 both encode the same isoform (1).
    Source sequence(s)
    AK127370, BC089387, BC144058, DA418635
    Consensus CDS
    CCDS55663.1
    UniProtKB/Swiss-Prot
    Q8NAT2
    Related
    ENSP00000406052.1, ENST00000444136.6
    Conserved Domains (5) summary
    cd04508
    Location:529575
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd09975
    Location:132201
    LOTUS_2_TDRD5; The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
    cd09976
    Location:296369
    LOTUS_3_TDRD5; The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
    cd09985
    Location:498
    LOTUS_1_TDRD5; The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
    pfam00567
    Location:471594
    TUDOR; Tudor domain
  2. NM_001199089.3NP_001186018.1  tudor domain-containing protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001186018.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (1).
    Source sequence(s)
    AK127370, BC043368, BC089387, BC130532, DA418635, DB073297
    Consensus CDS
    CCDS55663.1
    UniProtKB/Swiss-Prot
    Q8NAT2
    Conserved Domains (5) summary
    cd04508
    Location:529575
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd09975
    Location:132201
    LOTUS_2_TDRD5; The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
    cd09976
    Location:296369
    LOTUS_3_TDRD5; The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
    cd09985
    Location:498
    LOTUS_1_TDRD5; The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
    pfam00567
    Location:471594
    TUDOR; Tudor domain
  3. NM_001199091.2NP_001186020.1  tudor domain-containing protein 5 isoform 2

    See identical proteins and their annotated locations for NP_001186020.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal segment compared to isoform 1. Variants 3, 4, and 6 all encode the same isoform (2).
    Source sequence(s)
    AK126889, AL160286, BC043368, BC089387
    Consensus CDS
    CCDS1332.1
    UniProtKB/Swiss-Prot
    Q8NAT2
    UniProtKB/TrEMBL
    A0A024R910
    Related
    ENSP00000356586.1, ENST00000367614.5
    Conserved Domains (4) summary
    cd09975
    Location:132201
    LOTUS_2_TDRD5; The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
    cd09976
    Location:296369
    LOTUS_3_TDRD5; The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
    cd09985
    Location:498
    LOTUS_1_TDRD5; The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
    pfam00567
    Location:471594
    TUDOR; Tudor domain
  4. NM_001199092.2NP_001186021.1  tudor domain-containing protein 5 isoform 3

    See identical proteins and their annotated locations for NP_001186021.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks multiple exons from the 5' end and contains an alternate 5' exon, and lacks an in-frame coding exon compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AK092142, BC089387
    UniProtKB/Swiss-Prot
    Q8NAT2
    Conserved Domains (2) summary
    cd04508
    Location:84130
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:26149
    TUDOR; Tudor domain
  5. NM_001349923.1NP_001336852.1  tudor domain-containing protein 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 3, 4, and 6 all encode the same isoform (2).
    Source sequence(s)
    AL160286, AL590987
    Consensus CDS
    CCDS1332.1
    Conserved Domains (4) summary
    cd09975
    Location:132201
    LOTUS_2_TDRD5; The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
    cd09976
    Location:296369
    LOTUS_3_TDRD5; The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
    cd09985
    Location:498
    LOTUS_1_TDRD5; The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
    pfam00567
    Location:471594
    TUDOR; Tudor domain
  6. NM_173533.5NP_775804.2  tudor domain-containing protein 5 isoform 2

    See identical proteins and their annotated locations for NP_775804.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal segment compared to isoform 1. Variants 3, 4, and 6 all encode the same isoform (2).
    Source sequence(s)
    AK127370, BC043368, BC089387, DA418635
    Consensus CDS
    CCDS1332.1
    UniProtKB/Swiss-Prot
    Q8NAT2
    UniProtKB/TrEMBL
    A0A024R910
    Related
    ENSP00000294848.8, ENST00000294848.12
    Conserved Domains (4) summary
    cd09975
    Location:132201
    LOTUS_2_TDRD5; The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
    cd09976
    Location:296369
    LOTUS_3_TDRD5; The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
    cd09985
    Location:498
    LOTUS_1_TDRD5; The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
    pfam00567
    Location:471594
    TUDOR; Tudor domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    179591613..179691272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244935.4XP_005244992.1  tudor domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_005244992.1

    UniProtKB/Swiss-Prot
    Q8NAT2
    Conserved Domains (5) summary
    cd04508
    Location:529575
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd09975
    Location:132201
    LOTUS_2_TDRD5; The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
    cd09976
    Location:296369
    LOTUS_3_TDRD5; The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
    cd09985
    Location:498
    LOTUS_1_TDRD5; The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
    pfam00567
    Location:471594
    TUDOR; Tudor domain
  2. XM_005244934.1XP_005244991.1  tudor domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_005244991.1

    UniProtKB/Swiss-Prot
    Q8NAT2
    Conserved Domains (5) summary
    cd04508
    Location:529575
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd09975
    Location:132201
    LOTUS_2_TDRD5; The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
    cd09976
    Location:296369
    LOTUS_3_TDRD5; The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
    cd09985
    Location:498
    LOTUS_1_TDRD5; The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
    pfam00567
    Location:471594
    TUDOR; Tudor domain
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