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GBP6 guanylate binding protein family member 6 [ Homo sapiens (human) ]

Gene ID: 163351, updated on 13-Mar-2020

Summary

Official Symbol
GBP6provided by HGNC
Official Full Name
guanylate binding protein family member 6provided by HGNC
Primary source
HGNC:HGNC:25395
See related
Ensembl:ENSG00000183347 MIM:612467
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]
Expression
Restricted expression toward esophagus (RPKM 171.0) See more
Orthologs

Genomic context

See GBP6 in Genome Data Viewer
Location:
1p22.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (89363877..89388160)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89829436..89853719)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene guanylate binding protein family member 6 pseudogene Neighboring gene guanylate binding protein 5 Neighboring gene intraflagellar transport associated protein pseudogene Neighboring gene calpain small subunit 1 pseudogene 1 Neighboring gene guanylate binding protein 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39135, DKFZp686G0786

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular response to interferon-gamma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to interferon-gamma ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
symbiont-containing vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
guanylate-binding protein 6
Names
GBP-6
GTP-binding protein 6
guanine nucleotide-binding protein 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320257.1NP_001307186.1  guanylate-binding protein 6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses an downstream in-frame start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK299466, AK303987, AL691464, BX647907, DA437660, DA447005
    UniProtKB/TrEMBL
    B4DRX0, B4E1U2
    Conserved Domains (3) summary
    pfam02841
    Location:153449
    GBP_C; Guanylate-binding protein, C-terminal domain
    cd16269
    Location:159449
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:1151
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_198460.3NP_940862.2  guanylate-binding protein 6 isoform 1

    See identical proteins and their annotated locations for NP_940862.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI199897, AK131356, AL691464
    Consensus CDS
    CCDS723.1
    UniProtKB/Swiss-Prot
    Q6ZN66
    Related
    ENSP00000359485.4, ENST00000370456.4
    Conserved Domains (3) summary
    pfam02841
    Location:283579
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:18281
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:289579
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    89363877..89388160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540835.3XP_011539137.1  guanylate-binding protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011539137.1

    UniProtKB/Swiss-Prot
    Q6ZN66
    Conserved Domains (3) summary
    pfam02841
    Location:283579
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:18281
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:289579
    GBP_C; Guanylate-binding protein, C-terminal domain
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