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Fabp6 fatty acid binding protein 6 [ Mus musculus (house mouse) ]

Gene ID: 16204, updated on 8-Feb-2024

Summary

Official Symbol
Fabp6provided by MGI
Official Full Name
fatty acid binding protein 6provided by MGI
Primary source
MGI:MGI:96565
See related
Ensembl:ENSMUSG00000020405 AllianceGenome:MGI:96565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GT; ILBP; I-15P; ILBP3; Illbp; I-BABP
Summary
The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within the ileum, the distal 25-30% of the small intestine, and plays a role in enterohepatic circulation of bile acids and cholesterol homeostasis. In humans, it has been reported that polymorphisms in FABP6 confer a protective effect in obese individuals from developing type 2 diabetes. In mice deficiency of this gene affects bile acid metabolism in a gender-specific manner and was reported to be required for efficient apical to basolateral transport of conjugated bile acids. [provided by RefSeq, Jan 2013]
Expression
Restricted expression toward large intestine adult (RPKM 1460.5) See more
Orthologs
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Genomic context

See Fabp6 in Genome Data Viewer
Location:
11 B1.1; 11 25.81 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (43486867..43492389, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (43596040..43601562, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene C1q and tumor necrosis factor related protein 2 Neighboring gene STARR-seq mESC enhancer starr_29256 Neighboring gene cyclin J-like Neighboring gene STARR-seq mESC enhancer starr_29259 Neighboring gene STARR-seq mESC enhancer starr_29260 Neighboring gene predicted gene 12149 Neighboring gene STARR-seq mESC enhancer starr_29264 Neighboring gene STARR-seq mESC enhancer starr_29265 Neighboring gene 40S ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within bile acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
gastrotropin
Names
ileal bile acid-binding protein
ileal lipid-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008375.2NP_032401.1  gastrotropin

    See identical proteins and their annotated locations for NP_032401.1

    Status: REVIEWED

    Source sequence(s)
    BC119289, CJ043022
    Consensus CDS
    CCDS24560.1
    UniProtKB/Swiss-Prot
    P51162, Q5SRT9
    Related
    ENSMUSP00000020672.5, ENSMUST00000020672.5
    Conserved Domains (1) summary
    pfam14651
    Location:3128
    Lipocalin_7; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    43486867..43492389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)