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Il2ra interleukin 2 receptor, alpha chain [ Mus musculus (house mouse) ]

Gene ID: 16184, updated on 2-Nov-2024

Summary

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Official Symbol
Il2raprovided by MGI
Official Full Name
interleukin 2 receptor, alpha chainprovided by MGI
Primary source
MGI:MGI:96549
See related
Ensembl:ENSMUSG00000026770 AllianceGenome:MGI:96549
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD25; Il2r; Ly-43
Summary
Enables interleukin-2 binding activity and interleukin-2 receptor activity. Acts upstream of or within several processes, including Notch signaling pathway; activation-induced cell death of T cells; and regulation of T cell proliferation. Located in external side of plasma membrane. Is expressed in bone marrow and yolk sac. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thymus adult (RPKM 5.6), mammary gland adult (RPKM 1.1) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Il2ra in Genome Data Viewer
Location:
2 A1; 2 8.91 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (11647603..11698005)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (11642792..11693194)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03673 Neighboring gene RNA binding motif protein 17 Neighboring gene STARR-positive B cell enhancer ABC_E5883 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11558884-11559067 Neighboring gene STARR-positive B cell enhancer ABC_E9504 Neighboring gene STARR-positive B cell enhancer ABC_E5884 Neighboring gene STARR-positive B cell enhancer ABC_E5885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11577075-11577258 Neighboring gene STARR-seq mESC enhancer starr_03676 Neighboring gene predicted gene, 39760 Neighboring gene STARR-seq mESC enhancer starr_03677 Neighboring gene predicted gene, 39759 Neighboring gene interleukin 15 receptor, alpha chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements. Kim HP, et al. EMBO J, 2002 Jun 17. PMID 12065418, Free PMC Article
  2. Discovery of stimulation-responsive immune enhancers with CRISPR activation. Simeonov DR, et al. Nature, 2017 Sep 7. PMID 28854172, Free PMC Article
  3. Partial depletion of natural CD4⁺CD25⁺ regulatory T cells with anti-CD25 antibody does not alter the course of acute influenza A virus infection. Betts RJ, et al. PLoS One, 2011. PMID 22125630, Free PMC Article
  4. Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor. Van Parijs L, et al. J Immunol, 1997 Apr 15. PMID 9103438
  5. CD25+ T cells induce Helicobacter pylori-specific CD25- T-cell anergy but are not required to maintain persistent hyporesponsiveness. Stuller KA, et al. Eur J Immunol, 2008 Dec. PMID 19003932, Free PMC Article

See all (318) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-2Ralpha KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Ralpha in lymphoid and non-lymphoid cells.
    Title: IL-2Rα KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Rα in lymphoid and non-lymphoid cells.
  2. Conditional deletion of CD25 in the corneal epithelium reveals sex differences in barrier disruption.
    Title: Conditional deletion of CD25 in the corneal epithelium reveals sex differences in barrier disruption.
  3. Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function.
    Title: Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function.
  4. The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo.
    Title: The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo.
  5. Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25.
    Title: Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25.
  6. Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.
    Title: Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.
  7. Acute Lipopolysaccharide-Induced Inflammation Lowers IL-2R Signaling and the Proliferative Potential of Regulatory T Cells.
    Title: Acute Lipopolysaccharide-Induced Inflammation Lowers IL-2R Signaling and the Proliferative Potential of Regulatory T Cells.
  8. T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Ralpha-KO autoimmune mice.
    Title: T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice.
  9. CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation.
    Title: CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation.
  10. high-affinity T cells sustained IL-2R expression longer and expressed two novel Th cell differentiation regulators, Eef1e1 and Gbp2, to a higher level than low-affinity T cells.
    Title: TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.
Submit: New GeneRIF Correction See all GeneRIFs (114)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC130561

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables interleukin-2 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-2 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables interleukin-2 receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to interleukin-2 receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-2 receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-2-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-2-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of CD4-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of T cell homeostatic proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of T cell tolerance induction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of T cell tolerance induction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
interleukin-2 receptor subunit alpha
Names
IL-2 receptor subunit alpha
IL-2-RA
IL-2R alpha chain
IL-2R subunit alpha
IL2-RA
p55 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008367.3 → NP_032393.3  interleukin-2 receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_032393.3

    Status: VALIDATED

    Source sequence(s)
    AK037369, AL831794, BY200401
    Consensus CDS
    CCDS15685.1
    UniProtKB/Swiss-Prot
    P01590, Q61731
    UniProtKB/TrEMBL
    Q544I2, Q8C2H9
    Related
    ENSMUSP00000028111.5, ENSMUST00000028111.6
    Conserved Domains (1) summary
    cd00033
    Location:121 → 181
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    11647603..11698005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01590.1 GenPept UniProtKB/Swiss-Prot:P01590

Gene LinkOut

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