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Il2ra interleukin 2 receptor, alpha chain [ Mus musculus (house mouse) ]

Gene ID: 16184, updated on 5-Jan-2022

Summary

Official Symbol
Il2raprovided by MGI
Official Full Name
interleukin 2 receptor, alpha chainprovided by MGI
Primary source
MGI:MGI:96549
See related
Ensembl:ENSMUSG00000026770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD25; Il2r; Ly-43
Summary
Enables interleukin-2 binding activity and interleukin-2 receptor activity. Acts upstream of or within several processes, including Notch signaling pathway; activation-induced cell death of T cells; and regulation of T cell proliferation. Located in external side of plasma membrane. Is expressed in bone marrow. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in thymus adult (RPKM 5.6), mammary gland adult (RPKM 1.1) and 2 other tissues See more
Orthologs
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Genomic context

See Il2ra in Genome Data Viewer
Location:
2 A1; 2 8.91 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (11647603..11698005)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (11642792..11693194)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (11564419..11614821)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 17 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene Neighboring gene predicted gene, 39760 Neighboring gene predicted gene, 39759 Neighboring gene interleukin 15 receptor, alpha chain

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC130561

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables interleukin-2 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables interleukin-2 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-2 receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to interleukin-2 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-2 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of T cell homeostatic proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of T cell tolerance induction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-2 receptor subunit alpha
Names
IL-2 receptor subunit alpha
IL-2-RA
IL-2R alpha chain
IL-2R subunit alpha
IL2-RA
p55 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008367.3NP_032393.3  interleukin-2 receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_032393.3

    Status: VALIDATED

    Source sequence(s)
    AK037369, AL831794, BY200401
    Consensus CDS
    CCDS15685.1
    UniProtKB/Swiss-Prot
    P01590
    UniProtKB/TrEMBL
    Q544I2
    Related
    ENSMUSP00000028111.5, ENSMUST00000028111.6
    Conserved Domains (1) summary
    cd00033
    Location:121181
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    11647603..11698005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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