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Il13ra2 interleukin 13 receptor, alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 16165, updated on 1-Mar-2024

Summary

Official Symbol
Il13ra2provided by MGI
Official Full Name
interleukin 13 receptor, alpha 2provided by MGI
Primary source
MGI:MGI:1277954
See related
Ensembl:ENSMUSG00000031289 AllianceGenome:MGI:1277954
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD213a2; IL-13R-alpha-2
Summary
This gene encodes a receptor protein that binds to interleukin 13 (IL-13) with very high affinity. The encoded protein acts as a decoy receptor, and does not elicit any signal upon the binding of IL-13. Mice lacking the encoded protein exhibit increased levels of serum immunoglobulins, immune-dependent production of interferon gamma and, increased bone marrow macrophage progenitor frequency. Macrophages lacking the encoded protein release less nitric oxide and IL-12 in response to lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression
Biased expression in bladder adult (RPKM 1.3), frontal lobe adult (RPKM 0.3) and 2 other tissues See more
Orthologs
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Genomic context

See Il13ra2 in Genome Data Viewer
Location:
X F2; X 68.46 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (146166474..146214982, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (147383478..147429192, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 2C Neighboring gene microRNA 1911 Neighboring gene microRNA 448 Neighboring gene STARR-seq mESC enhancer starr_48057 Neighboring gene vomeronasal 1 receptor 239, pseudogene Neighboring gene predicted gene, 25107 Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
interleukin-13 receptor subunit alpha-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306059.1NP_001292988.1  interleukin-13 receptor subunit alpha-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001292988.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL662932, AL807780, BX005200
    UniProtKB/Swiss-Prot
    O88786
    Conserved Domains (1) summary
    pfam09240
    Location:136229
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  2. NM_008356.4NP_032382.1  interleukin-13 receptor subunit alpha-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032382.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL662932, AL807780, BX005200
    Consensus CDS
    CCDS30460.1
    UniProtKB/Swiss-Prot
    A3F812, O88786, Q3V2V5
    Related
    ENSMUSP00000033646.3, ENSMUST00000033646.9
    Conserved Domains (1) summary
    pfam09240
    Location:136229
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    146166474..146214982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528707.4XP_006528770.1  interleukin-13 receptor subunit alpha-2 isoform X1

    See identical proteins and their annotated locations for XP_006528770.1

    UniProtKB/Swiss-Prot
    A3F812, O88786, Q3V2V5
    Related
    ENSMUSP00000108446.2, ENSMUST00000112827.2
    Conserved Domains (1) summary
    pfam09240
    Location:136229
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  2. XM_030251234.2XP_030107094.1  interleukin-13 receptor subunit alpha-2 isoform X2

    Conserved Domains (1) summary
    pfam09240
    Location:136229
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  3. XM_017318395.2XP_017173884.1  interleukin-13 receptor subunit alpha-2 isoform X2

    UniProtKB/Swiss-Prot
    O88786
    Conserved Domains (1) summary
    pfam09240
    Location:136229
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  4. XM_036161826.1XP_036017719.1  interleukin-13 receptor subunit alpha-2 isoform X1

    UniProtKB/Swiss-Prot
    A3F812, O88786, Q3V2V5
    Conserved Domains (1) summary
    pfam09240
    Location:136229
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  5. XM_006528708.4XP_006528771.1  interleukin-13 receptor subunit alpha-2 isoform X1

    See identical proteins and their annotated locations for XP_006528771.1

    UniProtKB/Swiss-Prot
    A3F812, O88786, Q3V2V5
    Conserved Domains (1) summary
    pfam09240
    Location:136229
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding