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DAO D-amino acid oxidase [ Homo sapiens (human) ]

Gene ID: 1610, updated on 8-Jul-2018
Official Symbol
DAOprovided by HGNC
Official Full Name
D-amino acid oxidaseprovided by HGNC
Primary source
HGNC:HGNC:2671
See related
Ensembl:ENSG00000110887 MIM:124050; Vega:OTTHUMG00000169360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAAO; OXDA; DAMOX
Summary
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]
Expression
Biased expression in kidney (RPKM 37.6) and liver (RPKM 29.1) See more
Orthologs
See DAO in Genome Data Viewer
Location:
12q24.11
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (108880030..108901043)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109273806..109294710)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929204 Neighboring gene slingshot protein phosphatase 1 Neighboring gene microRNA 619 Neighboring gene SV2 related protein Neighboring gene RNA, U6 small nuclear 361, pseudogene Neighboring gene uncharacterized LOC105378256

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC35381

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D-amino-acid oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
D-amino-acid oxidase activity TAS
Traceable Author Statement
more info
 
FAD binding IDA
Inferred from Direct Assay
more info
PubMed 
cofactor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
D-alanine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
D-serine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
D-serine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular nitrogen compound metabolic process TAS
Traceable Author Statement
more info
 
dopamine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
proline catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
peroxisomal matrix TAS
Traceable Author Statement
more info
 
peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
D-amino-acid oxidase
NP_001908.3
XP_005268749.1
XP_011536306.1
XP_011536307.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023236.1 RefSeqGene

    Range
    5001..25854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001917.4NP_001908.3  D-amino-acid oxidase

    See identical proteins and their annotated locations for NP_001908.3

    Status: REVIEWED

    Source sequence(s)
    BC029057, BM932083, DA085245
    Consensus CDS
    CCDS9122.1
    UniProtKB/Swiss-Prot
    P14920
    UniProtKB/TrEMBL
    A0A024RBI1
    Related
    ENSP00000228476.3, OTTHUMP00000240887, ENST00000228476.7, OTTHUMT00000403682
    Conserved Domains (1) summary
    pfam01266
    Location:2329
    DAO; FAD dependent oxidoreductase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    108880030..108901043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268692.4XP_005268749.1  D-amino-acid oxidase isoform X2

    Related
    ENSP00000446853.1, OTTHUMP00000240886, ENST00000551281.5
    Conserved Domains (1) summary
    pfam01266
    Location:2307
    DAO; FAD dependent oxidoreductase
  2. XM_011538005.2XP_011536307.1  D-amino-acid oxidase isoform X1

    See identical proteins and their annotated locations for XP_011536307.1

    UniProtKB/Swiss-Prot
    P14920
    UniProtKB/TrEMBL
    A0A024RBI1
    Conserved Domains (1) summary
    pfam01266
    Location:2329
    DAO; FAD dependent oxidoreductase
  3. XM_011538004.2XP_011536306.1  D-amino-acid oxidase isoform X1

    See identical proteins and their annotated locations for XP_011536306.1

    UniProtKB/Swiss-Prot
    P14920
    UniProtKB/TrEMBL
    A0A024RBI1
    Conserved Domains (1) summary
    pfam01266
    Location:2329
    DAO; FAD dependent oxidoreductase
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