U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DGKQ diacylglycerol kinase theta [ Homo sapiens (human) ]

Gene ID: 1609, updated on 18-Sep-2024

Summary

Official Symbol
DGKQprovided by HGNC
Official Full Name
diacylglycerol kinase thetaprovided by HGNC
Primary source
HGNC:HGNC:2856
See related
Ensembl:ENSG00000145214 MIM:601207; AllianceGenome:HGNC:2856
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAGK; DAGK4; DAGK7
Summary
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in small intestine (RPKM 9.9), duodenum (RPKM 8.3) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DGKQ in Genome Data Viewer
Location:
4p16.3
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (958887..973569, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (956995..971678, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (952675..967357, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene cyclin G associated kinase Neighboring gene uncharacterized LOC105374341 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:872957-874156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:880593-881094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:881095-881594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:905677-906582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:906583-907488 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21140 Neighboring gene transmembrane protein 175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:938924-939517 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:957241-957400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:961731-962444 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:962445-963158 Neighboring gene uncharacterized LOC124900645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:963506-964024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:965861-966501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:973450-974030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21142 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:981121-981298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:983059-983560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:983561-984060 Neighboring gene solute carrier family 26 member 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:986529-987340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:987341-988152 Neighboring gene uncharacterized LOC124900646 Neighboring gene alpha-L-iduronidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
EBI GWAS Catalog
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
EBI GWAS Catalog
Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
EBI GWAS Catalog
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
EBI GWAS Catalog
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP-dependent diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP-dependent diacylglycerol kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ATP-dependent diacylglycerol kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ATP-dependent diacylglycerol kinase activity TAS
Traceable Author Statement
more info
 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables alkylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to bile acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in diacylglycerol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycerolipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipid phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of peptidyl-threonine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidic acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet activation TAS
Traceable Author Statement
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cortisol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of progesterone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in thrombin-activated receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
located_in vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
diacylglycerol kinase theta
Names
DAG kinase theta
DGK-theta
DGKtheta
diacylglycerol kinase, theta 110kDa
diglyceride kinase theta
testis tissue sperm-binding protein Li 38a
NP_001338.2
XP_011511713.1
XP_011511714.1
XP_011511716.1
XP_011511717.1
XP_047305643.1
XP_047305644.1
XP_054205037.1
XP_054205038.1
XP_054205039.1
XP_054205040.1
XP_054205041.1
XP_054205042.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347.4NP_001338.2  diacylglycerol kinase theta

    See identical proteins and their annotated locations for NP_001338.2

    Status: REVIEWED

    Source sequence(s)
    AB209503, AC019103, BC063801, DN990411
    Consensus CDS
    CCDS3342.1
    UniProtKB/Swiss-Prot
    P52824, Q6P3W4
    UniProtKB/TrEMBL
    A0A140VKC1, E9KL49
    Related
    ENSP00000273814.3, ENST00000273814.8
    Conserved Domains (6) summary
    cd01783
    Location:395492
    DAGK_delta_RA; Ubiquitin-like domain of Diacylgylcerol kinase (DAGK)
    smart00045
    Location:741893
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:590714
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:61108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00040
    Location:122169
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00155
    Location:296348
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    958887..973569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513411.2XP_011511713.1  diacylglycerol kinase theta isoform X2

    UniProtKB/TrEMBL
    E9KL49
    Conserved Domains (5) summary
    smart00045
    Location:741893
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:590714
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:61108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00040
    Location:122169
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00155
    Location:395475
    UBQ; Ubiquitin-like proteins
  2. XM_047449687.1XP_047305643.1  diacylglycerol kinase theta isoform X1

    UniProtKB/TrEMBL
    E9KL49
  3. XM_011513412.2XP_011511714.1  diacylglycerol kinase theta isoform X3

    Conserved Domains (5) summary
    cd01783
    Location:395492
    DAGK_delta_RA; Ubiquitin-like domain of Diacylgylcerol kinase (DAGK)
    cd00029
    Location:61108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00040
    Location:122169
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00155
    Location:296348
    UBQ; Ubiquitin-like proteins
    cl01255
    Location:590629
    DAGK_cat; Diacylglycerol kinase catalytic domain
  4. XM_011513414.3XP_011511716.1  diacylglycerol kinase theta isoform X4

    See identical proteins and their annotated locations for XP_011511716.1

    Conserved Domains (4) summary
    cd01783
    Location:395492
    DAGK_delta_RA; Ubiquitin-like domain of Diacylgylcerol kinase (DAGK)
    cd00029
    Location:61108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00040
    Location:122169
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00155
    Location:296348
    UBQ; Ubiquitin-like proteins
  5. XM_047449688.1XP_047305644.1  diacylglycerol kinase theta isoform X4

  6. XM_011513415.2XP_011511717.1  diacylglycerol kinase theta isoform X5

    Conserved Domains (3) summary
    cd00029
    Location:61108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00040
    Location:122169
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00155
    Location:395481
    UBQ; Ubiquitin-like proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    956995..971678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349063.1XP_054205038.1  diacylglycerol kinase theta isoform X2

    UniProtKB/TrEMBL
    E9KL49
  2. XM_054349062.1XP_054205037.1  diacylglycerol kinase theta isoform X1

    UniProtKB/TrEMBL
    E9KL49
  3. XM_054349064.1XP_054205039.1  diacylglycerol kinase theta isoform X3

  4. XM_054349066.1XP_054205041.1  diacylglycerol kinase theta isoform X4

  5. XM_054349065.1XP_054205040.1  diacylglycerol kinase theta isoform X4

  6. XM_054349067.1XP_054205042.1  diacylglycerol kinase theta isoform X5