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CLECL1 C-type lectin like 1 [ Homo sapiens (human) ]

Gene ID: 160365, updated on 5-Jan-2022

Summary

Official Symbol
CLECL1provided by HGNC
Official Full Name
C-type lectin like 1provided by HGNC
Primary source
HGNC:HGNC:24462
See related
Ensembl:ENSG00000184293 MIM:607467
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCAL1; DCAL-1
Summary
This gene encodes a type II transmembrane, C-type lectin-like protein that is highly expressed on dendritic and B cells. This protein may act as a T-cell costimulatory molecule that enhances interleukin-4 production, and maybe involved in the regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Biased expression in lymph node (RPKM 3.1), spleen (RPKM 2.6) and 11 other tissues See more
Orthologs
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Genomic context

See CLECL1 in Genome Data Viewer
Location:
12p13.31
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (9712973..9733296, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (9868456..9885895, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 2 member D Neighboring gene nucleophosmin 1 pseudogene 7 Neighboring gene long intergenic non-protein coding RNA 2390 Neighboring gene CRISPRi-validated cis-regulatory element chr12.520 Neighboring gene Sharpr-MPRA regulatory region 11505

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Other Names

  • C-type lectin-like domain family 1
  • DC-associated lectin-1
  • dendritic cell-associated lectin 1
  • type II transmembrane protein DCAL1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_172485.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007068
  2. NR_172486.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007068
    Related
    ENST00000327839.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    9712973..9733296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001253750.1: Suppressed sequence

    Description
    NM_001253750.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.
  2. NM_001267701.1: Suppressed sequence

    Description
    NM_001267701.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.
  3. NM_172004.3: Suppressed sequence

    Description
    NM_172004.3: This RefSeq was removed because it is now thought that this gene is a pseudogene.
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