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Ighg1 immunoglobulin heavy constant gamma 1 (G1m marker) [ Mus musculus (house mouse) ]

Gene ID: 16017, updated on 27-Sep-2022

Summary

Official Symbol
Ighg1provided by MGI
Official Full Name
immunoglobulin heavy constant gamma 1 (G1m marker)provided by MGI
Primary source
MGI:MGI:96446
See related
IMGT/GENE-DB:IGHG1; AllianceGenome:MGI:96446
Gene type
other
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IgG1; Igh-4; VH7183
Summary
Enables antigen binding activity and immunoglobulin receptor binding activity. Acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity; phagocytosis; and positive regulation of immune response. Located in external side of plasma membrane and extracellular space. Part of immunoglobulin complex, circulating. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)); and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Ighg1 in Genome Data Viewer
Location:
12 F1; 12 62.1 cM
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113290161..113294143, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113326541..113330523, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA40 Neighboring gene immunoglobulin heavy constant gamma 2B Neighboring gene immunoglobulin heavy chain complex Neighboring gene FUS interacting protein (serine-arginine rich) 1 pseudogene Neighboring gene Immunoglobulin heavy constant gamma 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • immunoglobulin heavy chain 4 (serum IgG1)
  • immunoglobulin heavy chain V region

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Fc-gamma receptor I complex binding ISO
Inferred from Sequence Orthology
more info
 
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables antigen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables immunoglobulin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within antibacterial humoral response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within antibody-dependent cellular cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within complement activation, classical pathway IDA
Inferred from Direct Assay
more info
 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within defense response to bacterium IDA
Inferred from Direct Assay
more info
 
acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within immunoglobulin mediated immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phagocytosis, engulfment IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phagocytosis, recognition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phagocytosis, recognition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of immune response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of type I hypersensitivity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of IgG immunoglobulin complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of immunoglobulin complex, circulating IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of immunoglobulin complex, circulating IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_005838.1 

    Range
    78945..82927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    113290161..113294143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)