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Igf2r insulin-like growth factor 2 receptor [ Mus musculus (house mouse) ]

Gene ID: 16004, updated on 19-Jun-2024

Summary

Official Symbol
Igf2rprovided by MGI
Official Full Name
insulin-like growth factor 2 receptorprovided by MGI
Primary source
MGI:MGI:96435
See related
Ensembl:ENSMUSG00000023830 AllianceGenome:MGI:96435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD222; CI-MPR; Mpr300; M6P/IGF2R
Summary
Enables insulin-like growth factor binding activity and mannose binding activity. Predicted to be involved in several processes, including liver development; positive regulation by host of viral process; and response to retinoic acid. Located in membrane and nuclear envelope lumen. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (insulin like growth factor 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 34.0), placenta adult (RPKM 24.7) and 28 other tissues See more
Orthologs
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Genomic context

See Igf2r in Genome Data Viewer
Location:
17 A1; 17 8.64 cM
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (12901293..12988593, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12682406..12769706, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 2 Neighboring gene STARR-seq mESC enhancer starr_41857 Neighboring gene solute carrier family 22 (organic cation transporter), member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:12938713-12938996 Neighboring gene antisense Igf2r RNA Neighboring gene VISTA enhancer mm89 Neighboring gene predicted gene, 49958 Neighboring gene RAN GTPase activating protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (10)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-mannose binding IDA
Inferred from Direct Assay
more info
PubMed 
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor II binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables insulin-like growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables retinoic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables retromer complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in liver development ISO
Inferred from Sequence Orthology
more info
 
involved_in lysosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
part_of clathrin coat ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network transport vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
cation-independent mannose-6-phosphate receptor
Names
300 kDa mannose 6-phosphate receptor
CI Man-6-P receptor
IGF-II receptor
IGF-II/CI-MPR
M6P/IGF2 receptor
M6PR
MPR 300
cation-independent MPR
insulin-like growth factor II receptor
mannose-6-phosphate receptor, cation independent

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010515.2NP_034645.2  cation-independent mannose-6-phosphate receptor precursor

    See identical proteins and their annotated locations for NP_034645.2

    Status: VALIDATED

    Source sequence(s)
    AC116804, AC167817, AK053045, BB865604, BP757292, BQ900123, CA324933, CD545656, CF167933, CK639250, CN461279, CN530622
    Consensus CDS
    CCDS37436.1
    UniProtKB/Swiss-Prot
    Q07113, Q61822, Q6LED1
    UniProtKB/TrEMBL
    B7ZWC4
    Related
    ENSMUSP00000024599.8, ENSMUST00000024599.14
    Conserved Domains (3) summary
    cd00062
    Location:18901935
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    pfam00878
    Location:10241171
    CIMR; Cation-independent mannose-6-phosphate receptor repeat
    pfam09451
    Location:335467
    ATG27; Autophagy-related protein 27

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    12901293..12988593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)