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SLC5A12 solute carrier family 5 member 12 [ Homo sapiens (human) ]

Gene ID: 159963, updated on 1-Jun-2020

Summary

Official Symbol
SLC5A12provided by HGNC
Official Full Name
solute carrier family 5 member 12provided by HGNC
Primary source
HGNC:HGNC:28750
See related
Ensembl:ENSG00000148942 MIM:612455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMCT2
Summary
Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]).[supplied by OMIM, Dec 2008]
Expression
Restricted expression toward kidney (RPKM 72.2) See more
Orthologs

Genomic context

See SLC5A12 in Genome Data Viewer
Location:
11p14.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (26667020..26723356, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (26688566..26743574, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene anoctamin 3 Neighboring gene uncharacterized LOC107987160 Neighboring gene mucin 15, cell surface associated Neighboring gene 11p14.2 distal LINE-mediated recombination region Neighboring gene fin bud initiation factor homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC52019, DKFZp564G223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lactate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organic acid:sodium symporter activity TAS
Traceable Author Statement
more info
 
symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ion transport TAS
Traceable Author Statement
more info
 
lactate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium-coupled monocarboxylate transporter 2
Names
electroneutral sodium monocarboxylate cotransporter
low-affinity sodium-lactate cotransporter
sodium-iodide related cotransporter
solute carrier family 5 (sodium/glucose cotransporter), member 12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178498.4NP_848593.2  sodium-coupled monocarboxylate transporter 2

    See identical proteins and their annotated locations for NP_848593.2

    Status: VALIDATED

    Source sequence(s)
    AC083755, AW614338, AY299482, BM924715, CN370367, CR747563
    Consensus CDS
    CCDS7860.2
    UniProtKB/Swiss-Prot
    Q1EHB4
    Related
    ENSP00000379326.3, ENST00000396005.8
    Conserved Domains (1) summary
    cd11520
    Location:3527
    SLC5sbd_SMCT2; Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    26667020..26723356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519920.2XP_011518222.1  sodium-coupled monocarboxylate transporter 2 isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:1339
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_006718155.3XP_006718218.1  sodium-coupled monocarboxylate transporter 2 isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:2416
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. XM_017017244.1XP_016872733.1  sodium-coupled monocarboxylate transporter 2 isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:1339
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. XM_011519921.2XP_011518223.1  sodium-coupled monocarboxylate transporter 2 isoform X4

    Related
    ENSP00000280467.6, ENST00000280467.10
    Conserved Domains (1) summary
    cl00456
    Location:3385
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  5. XM_006718156.3XP_006718219.1  sodium-coupled monocarboxylate transporter 2 isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:3407
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

  1. XR_930845.2 RNA Sequence

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