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Ifrd1 interferon-related developmental regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 15982, updated on 8-Feb-2024

Summary

Official Symbol
Ifrd1provided by MGI
Official Full Name
interferon-related developmental regulator 1provided by MGI
Primary source
MGI:MGI:1316717
See related
Ensembl:ENSMUSG00000001627 AllianceGenome:MGI:1316717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PC4; Ifnl; Tis7
Summary
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within several processes, including muscle cell differentiation; negative regulation of axonogenesis; and skeletal muscle tissue regeneration. Located in cytoplasm and nucleus. Is expressed in several structures, including extraembryonic component; liver and biliary system; nasal cavity epithelium; nervous system; and tooth. Orthologous to human IFRD1 (interferon related developmental regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine adult (RPKM 45.7), duodenum adult (RPKM 33.2) and 28 other tissues See more
Orthologs
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Genomic context

See Ifrd1 in Genome Data Viewer
Location:
12 B1; 12 18.06 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (40253128..40273184, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (40203129..40223189, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene scinderin Neighboring gene leucine-rich single-pass membrane protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:40926695-40926804 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:40949998-40950107 Neighboring gene microRNA 1938 Neighboring gene predicted gene 7008 Neighboring gene STARR-seq mESC enhancer starr_31954 Neighboring gene predicted gene, 40403

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interferon-related developmental regulator 1
Names
TPA-induced sequence 7
nerve growth factor-inducible protein PC4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013562.3NP_038590.2  interferon-related developmental regulator 1

    See identical proteins and their annotated locations for NP_038590.2

    Status: VALIDATED

    Source sequence(s)
    AC157571, AC174598
    Consensus CDS
    CCDS25893.1
    UniProtKB/Swiss-Prot
    P19182, P21835, P70228, Q80XM4
    UniProtKB/TrEMBL
    E9PVS0
    Related
    ENSMUSP00000001672.6, ENSMUST00000001672.12
    Conserved Domains (2) summary
    pfam04836
    Location:390443
    IFRD_C; Interferon-related protein conserved region
    pfam05004
    Location:40344
    IFRD; Interferon-related developmental regulator (IFRD)

RNA

  1. NR_181992.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157571, AC174598
  2. NR_181993.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157571, AC174598
  3. NR_181994.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157571, AC174598
  4. NR_181995.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157571, AC174598
  5. NR_181996.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157571, AC174598

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    40253128..40273184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)