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Ide insulin degrading enzyme [ Mus musculus (house mouse) ]

Gene ID: 15925, updated on 8-Feb-2024

Summary

Official Symbol
Ideprovided by MGI
Official Full Name
insulin degrading enzymeprovided by MGI
Primary source
MGI:MGI:96412
See related
Ensembl:ENSMUSG00000056999 AllianceGenome:MGI:96412
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300012G03Rik; 4833415K22Rik
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and peptide binding activity. Involved in insulin catabolic process. Acts upstream of or within amyloid-beta clearance and response to oxidative stress. Located in extracellular exosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 23.4), genital fat pad adult (RPKM 9.6) and 28 other tissues See more
Orthologs
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Genomic context

See Ide in Genome Data Viewer
Location:
19 C2; 19 32.24 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (37246140..37341664, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (37268743..37334544, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene galactose-3-O-sulfotransferase 1 pseudogene Neighboring gene RIKEN cDNA 4931408D14 gene Neighboring gene STARR-positive B cell enhancer ABC_E8748 Neighboring gene ribosomal protein L10, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_46050 Neighboring gene STARR-positive B cell enhancer ABC_E7648 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:37444922-37445105 Neighboring gene STARR-seq mESC enhancer starr_46052 Neighboring gene STARR-positive B cell enhancer ABC_E7649 Neighboring gene STARR-positive B cell enhancer ABC_E11674 Neighboring gene kinesin family member 11 Neighboring gene STARR-seq mESC enhancer starr_46054 Neighboring gene mortality factor 4 like 1 pseudogene Neighboring gene predicted gene, 46649

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-endorphin binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within amyloid-beta clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amyloid-beta clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in amyloid-beta clearance by cellular catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in amyloid-beta metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in amyloid-beta metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
Inferred from Sequence Orthology
more info
 
involved_in bradykinin catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hormone catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hormone catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin receptor recycling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis involved in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of aerobic respiration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin recycling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of cytosolic proteasome complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
insulin-degrading enzyme
Names
insulin protease
insulinase
insulysin
NP_112419.4
XP_036017334.1
XP_036017335.1
XP_036017336.1
XP_036017337.1
XP_036017338.1
XP_036017339.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031156.4NP_112419.4  insulin-degrading enzyme

    Status: VALIDATED

    Source sequence(s)
    AA163502, AJ278422, AK004972, AK078930, BU698019
    UniProtKB/Swiss-Prot
    Q9JHR7
    UniProtKB/TrEMBL
    F6RPJ9, Q8CGB9
    Related
    ENSMUSP00000121358.3, ENSMUST00000131070.3
    Conserved Domains (1) summary
    COG1025
    Location:45958
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    37246140..37341664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161446.1XP_036017339.1  insulin-degrading enzyme isoform X2

    UniProtKB/Swiss-Prot
    Q9JHR7
    Conserved Domains (1) summary
    COG1025
    Location:70983
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
  2. XM_036161441.1XP_036017334.1  insulin-degrading enzyme isoform X1

    UniProtKB/Swiss-Prot
    Q9JHR7
    Conserved Domains (1) summary
    COG1025
    Location:4917
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
  3. XM_036161444.1XP_036017337.1  insulin-degrading enzyme isoform X1

    UniProtKB/Swiss-Prot
    Q9JHR7
    Conserved Domains (1) summary
    COG1025
    Location:4917
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
  4. XM_036161443.1XP_036017336.1  insulin-degrading enzyme isoform X1

    UniProtKB/Swiss-Prot
    Q9JHR7
    Conserved Domains (1) summary
    COG1025
    Location:4917
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
  5. XM_036161445.1XP_036017338.1  insulin-degrading enzyme isoform X1

    UniProtKB/Swiss-Prot
    Q9JHR7
    Conserved Domains (1) summary
    COG1025
    Location:4917
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
  6. XM_036161442.1XP_036017335.1  insulin-degrading enzyme isoform X1

    UniProtKB/Swiss-Prot
    Q9JHR7
    Conserved Domains (1) summary
    COG1025
    Location:4917
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]