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Irf8 interferon regulatory factor 8 [ Mus musculus (house mouse) ]

Gene ID: 15900, updated on 27-Feb-2024

Summary

Official Symbol
Irf8provided by MGI
Official Full Name
interferon regulatory factor 8provided by MGI
Primary source
MGI:MGI:96395
See related
Ensembl:ENSMUSG00000041515 AllianceGenome:MGI:96395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myls; ICSBP; IRF-8; Icsbp1
Summary
The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression
Biased expression in spleen adult (RPKM 59.4), large intestine adult (RPKM 27.2) and 12 other tissues See more
Orthologs
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Genomic context

See Irf8 in Genome Data Viewer
Location:
8 E1; 8 70.05 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (121463097..121483433)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (120736358..120756694)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123225678-123225981 Neighboring gene STARR-positive B cell enhancer ABC_E6694 Neighboring gene mitochondrial ribosomal protein L30 pseudogene Neighboring gene predicted gene, 39266 Neighboring gene predicted gene, 33199

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in follicular B cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in germinal center B cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune system process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasmacytoid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon regulatory factor 8
Names
interferon consensus sequence binding protein 1
interferon consensus sequence-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301811.1NP_001288740.1  interferon regulatory factor 8

    See identical proteins and their annotated locations for NP_001288740.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK018533, AK137450, BF662476
    Consensus CDS
    CCDS22721.1
    UniProtKB/Swiss-Prot
    P23611
    UniProtKB/TrEMBL
    Q3U075, Q3U0X4, Q3U6F0, Q3UCV9, Q544J7
    Related
    ENSMUSP00000125029.2, ENSMUST00000162001.8
    Conserved Domains (2) summary
    pfam00605
    Location:9113
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:203379
    IRF-3; Interferon-regulatory factor 3
  2. NM_008320.4NP_032346.1  interferon regulatory factor 8

    See identical proteins and their annotated locations for NP_032346.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK018533, AK150370, AK151324, BF662476
    Consensus CDS
    CCDS22721.1
    UniProtKB/Swiss-Prot
    P23611
    UniProtKB/TrEMBL
    Q3U075, Q3U0X4, Q3U6F0, Q3UCV9, Q544J7
    Related
    ENSMUSP00000040245.4, ENSMUST00000047737.10
    Conserved Domains (2) summary
    pfam00605
    Location:9113
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:203379
    IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    121463097..121483433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)