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H2BW1 H2B.W histone 1 [ Homo sapiens (human) ]

Gene ID: 158983, updated on 31-Oct-2022

Summary

Official Symbol
H2BW1provided by HGNC
Official Full Name
H2B.W histone 1provided by HGNC
Primary source
HGNC:HGNC:27252
See related
Ensembl:ENSG00000123569 MIM:300507; AllianceGenome:HGNC:27252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2BFWT; TH2B-175
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family that is specifically expressed in sperm nuclei. A polymorphism in the 5' UTR of this gene is associated with male infertility.[provided by RefSeq, Oct 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See H2BW1 in Genome Data Viewer
Location:
Xq22.2
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (104011147..104013708, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102466207..102468768)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (103265719..103268280, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H2B.W histone 4, pseudogene Neighboring gene uncharacterized LOC107987334 Neighboring gene H2B.W histone 2 Neighboring gene uncharacterized LOC107985662

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC148130, MGC148131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone H2B type W-T
Names
H2B histone family member W, testis specific

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016406.2 RefSeqGene

    Range
    4981..7542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001002916.5NP_001002916.4  histone H2B type W-T

    Status: REVIEWED

    Source sequence(s)
    AC234782
    Consensus CDS
    CCDS35362.2
    Related
    ENSP00000354723.5, ENST00000217926.7
    Conserved Domains (1) summary
    cl23830
    Location:25138
    H2B; Histone H2B

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    104011147..104013708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    102466207..102468768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)