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MAGEB6 MAGE family member B6 [ Homo sapiens (human) ]

Gene ID: 158809, updated on 11-Jun-2021

Summary

Official Symbol
MAGEB6provided by HGNC
Official Full Name
MAGE family member B6provided by HGNC
Primary source
HGNC:HGNC:23796
See related
Ensembl:ENSG00000176746 MIM:300467
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT3.4; MAGE-B6; MAGEB6A
Summary
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is expressed in testis, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 2.3) See more
Orthologs
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Genomic context

See MAGEB6 in Genome Data Viewer
Location:
Xp21.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (26192440..26195646)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (26210557..26213763)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAGE family member B6B Neighboring gene MAGE family member B3 pseudogene Neighboring gene MAGE family member B5 Neighboring gene MAGE family member B3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40242

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
melanoma-associated antigen B6
Names
MAGE-B6 antigen
cancer/testis antigen 3.4
cancer/testis antigen family 3, member 4
melanoma antigen family B, 6
melanoma antigen family B6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013247.1 RefSeqGene

    Range
    5001..8207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173523.2NP_775794.2  melanoma-associated antigen B6

    See identical proteins and their annotated locations for NP_775794.2

    Status: REVIEWED

    Source sequence(s)
    AC005297
    Consensus CDS
    CCDS14217.1
    UniProtKB/Swiss-Prot
    Q8N7X4
    Related
    ENSP00000368320.1, ENST00000379034.1
    Conserved Domains (3) summary
    pfam01454
    Location:216370
    MAGE; MAGE family
    pfam12440
    Location:593
    MAGE_N; Melanoma associated antigen family N terminal
    cl00713
    Location:83181
    Auto_anti-p27; Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    26192440..26195646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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