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RHOXF1 Rhox homeobox family member 1 [ Homo sapiens (human) ]

Gene ID: 158800, updated on 5-Mar-2024

Summary

Official Symbol
RHOXF1provided by HGNC
Official Full Name
Rhox homeobox family member 1provided by HGNC
Primary source
HGNC:HGNC:29993
See related
Ensembl:ENSG00000101883 MIM:300446; AllianceGenome:HGNC:29993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OTEX; PEPP1
Summary
This gene is a member of the PEPP subfamily of paired-like homoebox genes. The gene may be regulated by androgens and epigenetic mechanisms. The encoded nuclear protein is likely a transcription factor that may play a role in human reproduction. [provided by RefSeq, Dec 2012]
Expression
Biased expression in testis (RPKM 4.9), fat (RPKM 1.1) and 2 other tissues See more
Orthologs
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Genomic context

See RHOXF1 in Genome Data Viewer
Location:
Xq24
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (120109051..120120438, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (118484211..118495405, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (119243009..119249823, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chrX:119148782-119148953 Neighboring gene Rhox homeobox family member 1 pseudogene 1 Neighboring gene RHOXF1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chrX:119177771-119178272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:119185571-119186072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:119186073-119186572 Neighboring gene Rhox homeobox family member 2B Neighboring gene ReSE screen-validated silencer GRCh37_chrX:119254442-119254623 Neighboring gene long intergenic non-protein coding RNA 1402 Neighboring gene Rhox homeobox family member 2 Neighboring gene SFR1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC119030, MGC119033

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in androgen receptor signaling pathway IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rhox homeobox family member 1
Names
PEPP subfamily gene 1
ovary-, testis- and epididymis-expressed gene protein
paired-like homeobox protein PEPP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139282.3NP_644811.1  rhox homeobox family member 1

    See identical proteins and their annotated locations for NP_644811.1

    Status: REVIEWED

    Source sequence(s)
    AC240732, AY099086, BE675048
    Consensus CDS
    CCDS14593.1
    UniProtKB/Swiss-Prot
    O95030, Q3SYE0, Q8NHV9
    Related
    ENSP00000217999.1, ENST00000217999.3
    Conserved Domains (1) summary
    cd00086
    Location:104162
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    120109051..120120438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531281.3XP_011529583.1  rhox homeobox family member 1 isoform X1

    Conserved Domains (1) summary
    cd00086
    Location:132190
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    118484211..118495405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326545.1XP_054182520.1  rhox homeobox family member 1 isoform X1