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ARHGAP36 Rho GTPase activating protein 36 [ Homo sapiens (human) ]

Gene ID: 158763, updated on 12-Oct-2019

Summary

Official Symbol
ARHGAP36provided by HGNC
Official Full Name
Rho GTPase activating protein 36provided by HGNC
Primary source
HGNC:HGNC:26388
See related
Ensembl:ENSG00000147256 MIM:300937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward adrenal (RPKM 54.0) See more
Orthologs

Genomic context

See ARHGAP36 in Genome Data Viewer
Location:
Xq26.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (131058346..131089885)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (130192216..130223859)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ecto-NOX disulfide-thiol exchanger 2 Neighboring gene uncharacterized LOC105373338 Neighboring gene long intergenic non-protein coding RNA 1201 Neighboring gene RNA, 7SL, cytoplasmic 191, pseudogene Neighboring gene olfactory receptor family 11 subfamily Q member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from BioSystems

  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 36

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282607.2NP_001269536.1  rho GTPase-activating protein 36 isoform 2

    See identical proteins and their annotated locations for NP_001269536.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region whihc results in the use of an alternate start codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA405456, AK296748, AL590131
    Consensus CDS
    CCDS65320.1
    UniProtKB/Swiss-Prot
    Q6ZRI8
    Related
    ENSP00000359960.1, ENST00000370922.5
    Conserved Domains (1) summary
    cd04376
    Location:215420
    RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...
  2. NM_001330651.1NP_001317580.1  rho GTPase-activating protein 36 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL590131
    Consensus CDS
    CCDS83489.1
    UniProtKB/Swiss-Prot
    Q6ZRI8
    Related
    ENSP00000359959.1, ENST00000370921.1
    Conserved Domains (1) summary
    cd04376
    Location:91296
    RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...
  3. NM_144967.4NP_659404.2  rho GTPase-activating protein 36 isoform 1 precursor

    See identical proteins and their annotated locations for NP_659404.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK128203, AL590131, BC063790, CD107623
    Consensus CDS
    CCDS14628.1
    UniProtKB/Swiss-Prot
    Q6ZRI8
    Related
    ENSP00000276211.5, ENST00000276211.10
    Conserved Domains (1) summary
    cd04376
    Location:227432
    RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    131058346..131089885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531280.1XP_011529582.1  rho GTPase-activating protein 36 isoform X1

    See identical proteins and their annotated locations for XP_011529582.1

    UniProtKB/Swiss-Prot
    Q6ZRI8
    Conserved Domains (1) summary
    cd04376
    Location:91296
    RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...
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