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ARHGAP36 Rho GTPase activating protein 36 [ Homo sapiens (human) ]

Gene ID: 158763, updated on 10-Dec-2024

Summary

Official Symbol
ARHGAP36provided by HGNC
Official Full Name
Rho GTPase activating protein 36provided by HGNC
Primary source
HGNC:HGNC:26388
See related
Ensembl:ENSG00000147256 MIM:300937; AllianceGenome:HGNC:26388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward adrenal (RPKM 54.0) See more
Orthologs
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Genomic context

See ARHGAP36 in Genome Data Viewer
Location:
Xq26.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (131058346..131089885)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (129378162..129409672)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (130192320..130223859)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ecto-NOX disulfide-thiol exchanger 2 Neighboring gene uncharacterized LOC124905217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29945 Neighboring gene H3K27ac hESC enhancers GRCh37_chrX:130036549-130037068 and GRCh37_chrX:130037069-130037588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:130093191-130093716 Neighboring gene long intergenic non-protein coding RNA 1201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130191672-130192325 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130192326-130192978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130206444-130207164 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:130218349-130219548 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chrX:130262358-130262858 Neighboring gene RNA, 7SL, cytoplasmic 191, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:130291947-130292676 Neighboring gene olfactory receptor family 11 subfamily Q member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ30058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282607.2NP_001269536.1  rho GTPase-activating protein 36 isoform 2

    See identical proteins and their annotated locations for NP_001269536.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region whihc results in the use of an alternate start codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA405456, AK296748, AL590131
    Consensus CDS
    CCDS65320.1
    UniProtKB/TrEMBL
    A0A2X0TVT1
    Related
    ENSP00000359960.1, ENST00000370922.5
    Conserved Domains (1) summary
    cd04376
    Location:215420
    RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...
  2. NM_001330651.1NP_001317580.1  rho GTPase-activating protein 36 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL590131
    Consensus CDS
    CCDS83489.1
    UniProtKB/Swiss-Prot
    Q6ZRI8
    Related
    ENSP00000359959.1, ENST00000370921.1
    Conserved Domains (1) summary
    cd04376
    Location:91296
    RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...
  3. NM_144967.4NP_659404.2  rho GTPase-activating protein 36 isoform 1 precursor

    See identical proteins and their annotated locations for NP_659404.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK128203, AL590131, BC063790, CD107623
    Consensus CDS
    CCDS14628.1
    UniProtKB/Swiss-Prot
    B7Z234, B7Z439, Q5JRL9, Q5JRM0, Q5JRM1, Q6ZRI8, Q96NU6
    UniProtKB/TrEMBL
    A0A2X0TVT1
    Related
    ENSP00000276211.5, ENST00000276211.10
    Conserved Domains (1) summary
    cd04376
    Location:227432
    RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    131058346..131089885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531280.2XP_011529582.1  rho GTPase-activating protein 36 isoform X1

    See identical proteins and their annotated locations for XP_011529582.1

    UniProtKB/Swiss-Prot
    Q6ZRI8
    Conserved Domains (1) summary
    cd04376
    Location:91296
    RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    129378162..129409672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326542.1XP_054182517.1  rho GTPase-activating protein 36 isoform X1