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KIAA2026 KIAA2026 [ Homo sapiens (human) ]

Gene ID: 158358, updated on 5-Aug-2022

Summary

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Official Symbol
KIAA2026provided by HGNC
Official Full Name
KIAA2026provided by HGNC
Primary source
HGNC:HGNC:23378
See related
Ensembl:ENSG00000183354 AllianceGenome:HGNC:23378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 4.2), thyroid (RPKM 2.9) and 25 other tissues See more
Orthologs
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Genomic context

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See KIAA2026 in Genome Data Viewer
Location:
9p24.1
Exon count:
18
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (5878834..6008482, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (5924176..6013620, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (5919022..6008482, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene endoplasmic reticulum metallopeptidase 1 Neighboring gene Sharpr-MPRA regulatory region 2314 Neighboring gene adenylate kinase 4 pseudogene 4 Neighboring gene small nucleolar RNA U13 Neighboring gene melan-A Neighboring gene microRNA 4665 Neighboring gene RAN binding protein 6 Neighboring gene uncharacterized LOC124902116

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. Uhler JP, et al. Biochem Biophys Res Commun, 2014 Jan 3. PMID 24211586
  2. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar FJ, et al. Mol Syst Biol, 2013 Oct 8. PMID 24104479, Free PMC Article
  3. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article
  4. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779, Free PMC Article
  5. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. Kovalski JR, et al. Mol Cell, 2019 Feb 21. PMID 30639242, Free PMC Article

See all (11) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
uncharacterized protein KIAA2026

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017969.3 → NP_001017969.2  uncharacterized protein KIAA2026

    See identical proteins and their annotated locations for NP_001017969.2

    Status: VALIDATED

    Source sequence(s)
    AL162384, AL365360, BC108654, DY655479
    UniProtKB/Swiss-Prot
    Q5HYC2, Q8IVE5
    Related
    ENSP00000382815.3, ENST00000399933.8
    Conserved Domains (3) summary
    cd04369
    Location:137 → 193
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    pfam05672
    Location:253 → 292
    MAP7; MAP7 (E-MAP-115) family
    pfam06936
    Location:225 → 287
    Selenoprotein_S; Selenoprotein S (SelS)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    5878834..6008482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517760.4 → XP_011516062.1  uncharacterized protein KIAA2026 isoform X3

    See identical proteins and their annotated locations for XP_011516062.1

    Conserved Domains (4) summary
    cd04369
    Location:137 → 193
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    PHA03255
    Location:1668 → 1825
    PHA03255; BDLF3; Provisional
    pfam05109
    Location:1180 → 1760
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam06936
    Location:225 → 287
    Selenoprotein_S; Selenoprotein S (SelS)

  2. XM_011517759.4 → XP_011516061.1  uncharacterized protein KIAA2026 isoform X3

    See identical proteins and their annotated locations for XP_011516061.1

    Conserved Domains (4) summary
    cd04369
    Location:137 → 193
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    PHA03255
    Location:1668 → 1825
    PHA03255; BDLF3; Provisional
    pfam05109
    Location:1180 → 1760
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam06936
    Location:225 → 287
    Selenoprotein_S; Selenoprotein S (SelS)

  3. XM_047422861.1 → XP_047278817.1  uncharacterized protein KIAA2026 isoform X6

  4. XM_017014331.3 → XP_016869820.1  uncharacterized protein KIAA2026 isoform X2

  5. XM_005251385.4 → XP_005251442.1  uncharacterized protein KIAA2026 isoform X1

    UniProtKB/Swiss-Prot
    Q5HYC2
    Related
    ENSP00000370870.2, ENST00000381461.6
    Conserved Domains (3) summary
    cd04369
    Location:137 → 193
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    pfam05672
    Location:253 → 292
    MAP7; MAP7 (E-MAP-115) family
    pfam06936
    Location:225 → 287
    Selenoprotein_S; Selenoprotein S (SelS)

  6. XM_047422860.1 → XP_047278816.1  uncharacterized protein KIAA2026 isoform X5

  7. XM_024447429.2 → XP_024303197.1  uncharacterized protein KIAA2026 isoform X4

  8. XM_011517761.3 → XP_011516063.1  uncharacterized protein KIAA2026 isoform X5

    See identical proteins and their annotated locations for XP_011516063.1

    UniProtKB/Swiss-Prot
    Q5HYC2

  9. XM_047422862.1 → XP_047278818.1  uncharacterized protein KIAA2026 isoform X7

RNA

  1. XR_007061251.1 RNA Sequence

  2. XR_007061249.1 RNA Sequence

  3. XR_007061250.1 RNA Sequence

  4. XR_007061252.1 RNA Sequence

  5. XR_001746198.3 RNA Sequence

  6. XR_001746203.3 RNA Sequence

  7. XR_001746207.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    5924176..6013620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HYC2.2 GenPept UniProtKB/Swiss-Prot:Q5HYC2

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