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BRD10 bromodomain containing 10 [ Homo sapiens (human) ]

Gene ID: 158358, updated on 5-Jul-2025
Official Symbol
BRD10provided by HGNC
Official Full Name
bromodomain containing 10provided by HGNC
Primary source
HGNC:HGNC:23378
See related
Ensembl:ENSG00000183354 AllianceGenome:HGNC:23378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA2026
Summary
Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in testis (RPKM 4.2), thyroid (RPKM 2.9) and 25 other tissues See more
Orthologs
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See BRD10 in Genome Data Viewer
Location:
9p24.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (5878834..6008482, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (5881968..6013620, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (5919022..6008482, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RIC1 partner of RAB6A GEF complex Neighboring gene uncharacterized LOC124902115 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:5762408-5763607 Neighboring gene endoplasmic reticulum metallopeptidase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19756 Neighboring gene Sharpr-MPRA regulatory region 2314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19757 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:5879621-5880122 Neighboring gene small nucleolar RNA U13 Neighboring gene adenylate kinase 4 pseudogene 4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:5909826-5911025 Neighboring gene melan-A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19759 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:6007511-6008012 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:6008013-6008512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19762 Neighboring gene microRNA 4665 Neighboring gene RAN binding protein 6 Neighboring gene uncharacterized LOC124902116

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Writers and readers of histone acetylation: structure, mechanism, and inhibition. Marmorstein R, et al. Cold Spring Harb Perspect Biol, 2014 Jul 1. PMID 24984779, Free PMC Article
  2. The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. Uhler JP, et al. Biochem Biophys Res Commun, 2014 Jan 3. PMID 24211586
  3. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar FJ, et al. Mol Syst Biol, 2013 Oct 8. PMID 24104479, Free PMC Article
  4. SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9. Schmidt N, et al. Cell, 2023 Oct 26. PMID 37794589, Free PMC Article
  5. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
uncharacterized bromodomain-containing protein 10

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017969.3 → NP_001017969.2  uncharacterized bromodomain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_001017969.2

    Status: VALIDATED

    Source sequence(s)
    AL162384, AL365360, BC108654, DY655479
    UniProtKB/Swiss-Prot
    A8MTP2, B9EGW7, Q4VXA2, Q5HYC2, Q8IVE5
    Related
    ENSP00000382815.3, ENST00000399933.8
    Conserved Domains (3) summary
    cd04369
    Location:137 → 193
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    pfam05672
    Location:253 → 292
    MAP7; MAP7 (E-MAP-115) family
    pfam06936
    Location:225 → 287
    Selenoprotein_S; Selenoprotein S (SelS)

  2. NM_001438917.1 → NP_001425846.1  uncharacterized bromodomain-containing protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL162384, AL353606, AL365360

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    5878834..6008482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517760.4 → XP_011516062.1  uncharacterized bromodomain-containing protein 10 isoform X3

    See identical proteins and their annotated locations for XP_011516062.1

    Conserved Domains (4) summary
    cd04369
    Location:137 → 193
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    PHA03255
    Location:1668 → 1825
    PHA03255; BDLF3; Provisional
    pfam05109
    Location:1180 → 1760
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam06936
    Location:225 → 287
    Selenoprotein_S; Selenoprotein S (SelS)

  2. XM_011517759.4 → XP_011516061.1  uncharacterized bromodomain-containing protein 10 isoform X3

    See identical proteins and their annotated locations for XP_011516061.1

    Conserved Domains (4) summary
    cd04369
    Location:137 → 193
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    PHA03255
    Location:1668 → 1825
    PHA03255; BDLF3; Provisional
    pfam05109
    Location:1180 → 1760
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam06936
    Location:225 → 287
    Selenoprotein_S; Selenoprotein S (SelS)

  3. XM_047422861.1 → XP_047278817.1  uncharacterized bromodomain-containing protein 10 isoform X6

  4. XM_017014331.3 → XP_016869820.1  uncharacterized bromodomain-containing protein 10 isoform X2

  5. XM_005251385.4 → XP_005251442.1  uncharacterized bromodomain-containing protein 10 isoform X1

    UniProtKB/Swiss-Prot
    Q5HYC2
    Related
    ENSP00000370870.2, ENST00000381461.6
    Conserved Domains (3) summary
    cd04369
    Location:137 → 193
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    pfam05672
    Location:253 → 292
    MAP7; MAP7 (E-MAP-115) family
    pfam06936
    Location:225 → 287
    Selenoprotein_S; Selenoprotein S (SelS)

  6. XM_047422860.1 → XP_047278816.1  uncharacterized bromodomain-containing protein 10 isoform X5

  7. XM_024447429.2 → XP_024303197.1  uncharacterized bromodomain-containing protein 10 isoform X4

  8. XM_011517761.3 → XP_011516063.1  uncharacterized bromodomain-containing protein 10 isoform X5

    See identical proteins and their annotated locations for XP_011516063.1

    UniProtKB/Swiss-Prot
    Q5HYC2

  9. XM_047422862.1 → XP_047278818.1  uncharacterized bromodomain-containing protein 10 isoform X7

RNA

  1. XR_007061251.1 RNA Sequence

  2. XR_007061249.1 RNA Sequence

  3. XR_007061250.1 RNA Sequence

  4. XR_007061252.1 RNA Sequence

  5. XR_001746198.3 RNA Sequence

  6. XR_001746203.3 RNA Sequence

  7. XR_001746207.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    5881968..6013620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362141.1 → XP_054218116.1  uncharacterized bromodomain-containing protein 10 isoform X3

  2. XM_054362145.1 → XP_054218120.1  uncharacterized bromodomain-containing protein 10 isoform X6

  3. XM_054362140.1 → XP_054218115.1  uncharacterized bromodomain-containing protein 10 isoform X1

  4. XM_054362143.1 → XP_054218118.1  uncharacterized bromodomain-containing protein 10 isoform X5

  5. XM_054362142.1 → XP_054218117.1  uncharacterized bromodomain-containing protein 10 isoform X4

  6. XM_054362144.1 → XP_054218119.1  uncharacterized bromodomain-containing protein 10 isoform X5

  7. XM_054362146.1 → XP_054218121.1  uncharacterized bromodomain-containing protein 10 isoform X7

RNA

  1. XR_008487947.1 RNA Sequence

  2. XR_008487946.1 RNA Sequence

  3. XR_008487948.1 RNA Sequence

  4. XR_008487949.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HYC2.2 GenPept UniProtKB/Swiss-Prot:Q5HYC2

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