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CAMSAP1 calmodulin regulated spectrin associated protein 1 [ Homo sapiens (human) ]

Gene ID: 157922, updated on 13-Mar-2020

Summary

Official Symbol
CAMSAP1provided by HGNC
Official Full Name
calmodulin regulated spectrin associated protein 1provided by HGNC
Primary source
HGNC:HGNC:19946
See related
Ensembl:ENSG00000130559 MIM:613774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 12.5), brain (RPKM 9.1) and 25 other tissues See more
Orthologs

Genomic context

See CAMSAP1 in Genome Data Viewer
Location:
9q34.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (135808487..135907551, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (138700333..138799060, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene potassium sodium-activated channel subfamily T member 1 Neighboring gene uncharacterized LOC107987139 Neighboring gene uncharacterized LOC107987140 Neighboring gene Sharpr-MPRA regulatory region 8889 Neighboring gene uncharacterized LOC107987141 Neighboring gene UBA domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31228, MGC163452, DKFZp434F195, DKFZp434G2311

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule minus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
spectrin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule minus-end IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with microtubule minus-end IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calmodulin-regulated spectrin-associated protein 1
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015447.4NP_056262.3  calmodulin-regulated spectrin-associated protein 1

    See identical proteins and their annotated locations for NP_056262.3

    Status: VALIDATED

    Source sequence(s)
    AL355574, AL834528, AW448941, BC130580, BU949503
    Consensus CDS
    CCDS35176.2
    UniProtKB/Swiss-Prot
    Q5T5Y3
    Related
    ENSP00000374183.4, ENST00000389532.9
    Conserved Domains (4) summary
    smart01051
    Location:14631591
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:229312
    CAMSAP_CH; CAMSAP CH domain
    pfam15346
    Location:12761353
    ARGLU; Arginine and glutamate-rich 1
    pfam17095
    Location:870921
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    135808487..135907551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263396.3XP_005263453.1  calmodulin-regulated spectrin-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T5Y3
    Related
    ENSP00000386420.3, ENST00000409386.3
    Conserved Domains (5) summary
    smart01051
    Location:14741602
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:240323
    CAMSAP_CH; CAMSAP CH domain
    pfam13863
    Location:12851366
    DUF4200; Domain of unknown function (DUF4200)
    pfam15346
    Location:12871364
    ARGLU; Arginine and glutamate-rich 1
    pfam17095
    Location:881932
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  2. XM_011518274.1XP_011516576.1  calmodulin-regulated spectrin-associated protein 1 isoform X4

    Conserved Domains (5) summary
    smart01051
    Location:12641392
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:30113
    CAMSAP_CH; CAMSAP CH domain
    pfam13863
    Location:10751156
    DUF4200; Domain of unknown function (DUF4200)
    pfam15346
    Location:10771154
    ARGLU; Arginine and glutamate-rich 1
    pfam17095
    Location:671722
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  3. XM_011518272.1XP_011516574.1  calmodulin-regulated spectrin-associated protein 1 isoform X2

    Conserved Domains (5) summary
    smart01051
    Location:13301458
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:96179
    CAMSAP_CH; CAMSAP CH domain
    pfam13863
    Location:11411222
    DUF4200; Domain of unknown function (DUF4200)
    pfam15346
    Location:11431220
    ARGLU; Arginine and glutamate-rich 1
    pfam17095
    Location:737788
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  4. XM_011518273.2XP_011516575.1  calmodulin-regulated spectrin-associated protein 1 isoform X3

    Conserved Domains (5) summary
    smart01051
    Location:12751403
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:41124
    CAMSAP_CH; CAMSAP CH domain
    pfam13863
    Location:10861167
    DUF4200; Domain of unknown function (DUF4200)
    pfam15346
    Location:10881165
    ARGLU; Arginine and glutamate-rich 1
    pfam17095
    Location:682733
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  5. XM_005263397.1XP_005263454.1  calmodulin-regulated spectrin-associated protein 1 isoform X5

    See identical proteins and their annotated locations for XP_005263454.1

    UniProtKB/Swiss-Prot
    Q5T5Y3
    Related
    ENSP00000312463.6, ENST00000312405.10
    Conserved Domains (5) summary
    smart01051
    Location:11851313
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam13863
    Location:9961077
    DUF4200; Domain of unknown function (DUF4200)
    pfam15346
    Location:9981075
    ARGLU; Arginine and glutamate-rich 1
    pfam17095
    Location:592643
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    cl00030
    Location:134
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
  6. XM_017014301.1XP_016869790.1  calmodulin-regulated spectrin-associated protein 1 isoform X2

    Conserved Domains (5) summary
    smart01051
    Location:13301458
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:96179
    CAMSAP_CH; CAMSAP CH domain
    pfam13863
    Location:11411222
    DUF4200; Domain of unknown function (DUF4200)
    pfam15346
    Location:11431220
    ARGLU; Arginine and glutamate-rich 1
    pfam17095
    Location:737788
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  7. XM_017014302.1XP_016869791.1  calmodulin-regulated spectrin-associated protein 1 isoform X2

    Conserved Domains (5) summary
    smart01051
    Location:13301458
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:96179
    CAMSAP_CH; CAMSAP CH domain
    pfam13863
    Location:11411222
    DUF4200; Domain of unknown function (DUF4200)
    pfam15346
    Location:11431220
    ARGLU; Arginine and glutamate-rich 1
    pfam17095
    Location:737788
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
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