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TMEM74 transmembrane protein 74 [ Homo sapiens (human) ]

Gene ID: 157753, updated on 11-Jun-2021

Summary

Official Symbol
TMEM74provided by HGNC
Official Full Name
transmembrane protein 74provided by HGNC
Primary source
HGNC:HGNC:26409
See related
Ensembl:ENSG00000164841 MIM:613935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET36
Expression
Biased expression in brain (RPKM 1.7), heart (RPKM 0.4) and 6 other tissues See more
Orthologs
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Genomic context

See TMEM74 in Genome Data Viewer
Location:
8q23.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (108606850..108787594, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (109619079..109799823, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ER membrane protein complex subunit 2 Neighboring gene dnaJ homolog subfamily B member 6-like Neighboring gene uncharacterized LOC102723368 Neighboring gene uncharacterized LOC101927413 Neighboring gene uncharacterized LOC107984017

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30668

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in autophagosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153015.3NP_694560.1  transmembrane protein 74

    See identical proteins and their annotated locations for NP_694560.1

    Status: VALIDATED

    Source sequence(s)
    AC104247, AK055230, BC030710, D60265
    Consensus CDS
    CCDS6310.1
    UniProtKB/Swiss-Prot
    Q96NL1
    UniProtKB/TrEMBL
    A0A024R9D4
    Related
    ENSP00000297459.3, ENST00000297459.4
    Conserved Domains (1) summary
    pfam14927
    Location:154262
    Neurensin; Neurensin

RNA

  1. NR_136411.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC022634, BC030710, BC033057
    Related
    ENST00000518838.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    108606850..108787594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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