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Htr4 5 hydroxytryptamine (serotonin) receptor 4 [ Mus musculus (house mouse) ]

Gene ID: 15562, updated on 9-Mar-2023

Summary

Official Symbol
Htr4provided by MGI
Official Full Name
5 hydroxytryptamine (serotonin) receptor 4provided by MGI
Primary source
MGI:MGI:109246
See related
Ensembl:ENSMUSG00000026322 AllianceGenome:MGI:109246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5-HT4; 5HTR4; 5-HT-4; 5-HT<4L>
Summary
Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; chemical synaptic transmission; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and spinal cord. Used to study anorexia nervosa. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 1.5), colon adult (RPKM 1.5) and 6 other tissues See more
Orthologs
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Genomic context

See Htr4 in Genome Data Viewer
Location:
18; 18 E1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (62456618..62636098)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62323546..62503027)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9949 Neighboring gene adrenergic receptor, beta 2 Neighboring gene predicted gene, 36124 Neighboring gene predicted gene, 36316 Neighboring gene X-linked lymphocyte-regulated 5C pseudogene Neighboring gene F-box protein 38 Neighboring gene serine peptidase inhibitor, Kazal type 10 Neighboring gene serine peptidase inhibitor, Kazal type 7 (putative)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled serotonin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serotonin receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
5-hydroxytryptamine receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364956.1NP_001351885.1  5-hydroxytryptamine receptor 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC152454
    Consensus CDS
    CCDS89255.1
    UniProtKB/TrEMBL
    A0A494BA82
    Related
    ENSMUSP00000157982.2, ENSMUST00000237114.2
    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001364957.1NP_001351886.1  5-hydroxytryptamine receptor 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC152454
    Consensus CDS
    CCDS89257.1
    Related
    ENSMUSP00000157967.2, ENSMUST00000238081.2
    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001364958.1NP_001351887.1  5-hydroxytryptamine receptor 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC152454
    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001364959.1NP_001351888.1  5-hydroxytryptamine receptor 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC152454
    Consensus CDS
    CCDS89256.1
    Related
    ENSMUSP00000157470.2, ENSMUST00000236691.2
    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_008313.4NP_032339.2  5-hydroxytryptamine receptor 4 isoform 1

    See identical proteins and their annotated locations for NP_032339.2

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC152454
    Consensus CDS
    CCDS29291.1
    UniProtKB/Swiss-Prot
    P97288, Q9R2A4
    Related
    ENSMUSP00000027560.7, ENSMUST00000027560.8
    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    62456618..62636098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250347.2XP_030106207.1  5-hydroxytryptamine receptor 4 isoform X6

    Conserved Domains (2) summary
    cd14964
    Location:2147
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:20118
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_006525682.5XP_006525745.1  5-hydroxytryptamine receptor 4 isoform X3

    See identical proteins and their annotated locations for XP_006525745.1

    UniProtKB/TrEMBL
    A0A494BA82
    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_006525681.5XP_006525744.1  5-hydroxytryptamine receptor 4 isoform X3

    See identical proteins and their annotated locations for XP_006525744.1

    UniProtKB/TrEMBL
    A0A494BA82
    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_006525683.5XP_006525746.1  5-hydroxytryptamine receptor 4 isoform X4

    See identical proteins and their annotated locations for XP_006525746.1

    UniProtKB/Swiss-Prot
    P97288
    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_030250345.2XP_030106205.1  5-hydroxytryptamine receptor 4 isoform X2

    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. XM_011246848.4XP_011245150.1  5-hydroxytryptamine receptor 4 isoform X5

    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  7. XM_006525680.5XP_006525743.1  5-hydroxytryptamine receptor 4 isoform X2

    See identical proteins and their annotated locations for XP_006525743.1

    UniProtKB/Swiss-Prot
    P97288
    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  8. XM_030250344.2XP_030106204.1  5-hydroxytryptamine receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9R2A4
    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  9. XM_030250343.2XP_030106203.1  5-hydroxytryptamine receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9R2A4
    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  10. XM_006525676.5XP_006525739.1  5-hydroxytryptamine receptor 4 isoform X1

    See identical proteins and their annotated locations for XP_006525739.1

    UniProtKB/Swiss-Prot
    P97288, Q9R2A4
    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  11. XM_006525678.5XP_006525741.1  5-hydroxytryptamine receptor 4 isoform X1

    See identical proteins and their annotated locations for XP_006525741.1

    UniProtKB/Swiss-Prot
    P97288, Q9R2A4
    Conserved Domains (1) summary
    cd15056
    Location:20323
    7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors