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CYP2A13 cytochrome P450 family 2 subfamily A member 13 [ Homo sapiens (human) ]

Gene ID: 1553, updated on 8-Dec-2018

Summary

Official Symbol
CYP2A13provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily A member 13provided by HGNC
Primary source
HGNC:HGNC:2608
See related
Ensembl:ENSG00000197838 MIM:608055
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPAD; CYP2A; CYPIIA13
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 9.1) See more
Orthologs

Genomic context

See CYP2A13 in Genome Data Viewer
Location:
19q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (41088451..41096195)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41594356..41602100)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily A member 7 pseudogene 1 Neighboring gene cytochrome P450 family 2 subfamily G member 2, pseudogene Neighboring gene cytochrome P450 family 2 subfamily F member 1 Neighboring gene cytochrome P450 family 2 subfamily T member 3, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arachidonic acid epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
coumarin 7-hydroxylase activity TAS
Traceable Author Statement
more info
 
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity TAS
Traceable Author Statement
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
coumarin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
coumarin metabolic process TAS
Traceable Author Statement
more info
 
epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exogenous drug catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organelle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 2A13
Names
cytochrome P450, family 2, subfamily A, polypeptide 13
cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 13
NP_000757.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007928.1 RefSeqGene

    Range
    4989..12733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000766.4NP_000757.2  cytochrome P450 2A13

    See identical proteins and their annotated locations for NP_000757.2

    Status: REVIEWED

    Source sequence(s)
    AC008962, AF209774, BM975825
    Consensus CDS
    CCDS12571.1
    UniProtKB/Swiss-Prot
    Q16696
    Related
    ENSP00000332679.1, ENST00000330436.3
    Conserved Domains (1) summary
    pfam00067
    Location:34491
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    41088451..41096195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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