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Skap2 src kinase associated phosphoprotein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 155183, updated on 17-Aug-2024

Summary

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Official Symbol
Skap2provided by RGD
Official Full Name
src kinase associated phosphoprotein 2provided by RGD
Primary source
RGD:620159
See related
EnsemblRapid:ENSRNOG00000012228 AllianceGenome:RGD:620159
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Scap2; Scap55r
Summary
Predicted to be involved in B cell activation. Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human SKAP2 (src kinase associated phosphoprotein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 296.6), Spleen (RPKM 224.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q24
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (82281221..82431664, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (80948832..81100900, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (81816778..81968832, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102273 Neighboring gene uncharacterized LOC120102274 Neighboring gene uncharacterized LOC134486768 Neighboring gene uncharacterized LOC102550087 Neighboring gene 60S ribosomal protein L31 pseudogene Neighboring gene uncharacterized LOC120102275

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest. Curtis DJ, et al. Exp Hematol, 2000 Nov. PMID 11063873
  2. The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. Kirchgessner H, et al. J Exp Med, 2001 Jun 4. PMID 11390434, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in B cell activation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
src kinase-associated phosphoprotein 2
Names
SKAP-55HOM
SKAP-HOM
SKAP55 homolog
SKAP55-HOM
src family-associated phosphoprotein 2
src kinase-associated phosphoprotein 55-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130413.1 → NP_569097.1  src kinase-associated phosphoprotein 2

    See identical proteins and their annotated locations for NP_569097.1

    Status: PROVISIONAL

    Source sequence(s)
    AF302132
    UniProtKB/Swiss-Prot
    Q920G0
    UniProtKB/TrEMBL
    A0A8I6A1S5, A6K0P7
    Related
    ENSRNOP00000085492.1, ENSRNOT00000106495.2
    Conserved Domains (2) summary
    cd13381
    Location:117 → 222
    PH_Skap-hom_Skap2; Src kinase-associated phosphoprotein homolog and Skap 2 Pleckstrin homology (PH) domain
    cl17036
    Location:300 → 352
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    82281221..82431664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236477.5 → XP_006236539.1  src kinase-associated phosphoprotein 2 isoform X1

    See identical proteins and their annotated locations for XP_006236539.1

    UniProtKB/Swiss-Prot
    Q920G0
    UniProtKB/TrEMBL
    A0A8I6A1S5, A6K0P7
    Related
    ENSRNOP00000016608.3, ENSRNOT00000016608.4
    Conserved Domains (2) summary
    cd13381
    Location:117 → 222
    PH_Skap-hom_Skap2; Src kinase-associated phosphoprotein homolog and Skap 2 Pleckstrin homology (PH) domain
    cl17036
    Location:300 → 352
    SH3; Src Homology 3 domain superfamily

  2. XM_006236478.5 → XP_006236540.1  src kinase-associated phosphoprotein 2 isoform X1

    See identical proteins and their annotated locations for XP_006236540.1

    UniProtKB/Swiss-Prot
    Q920G0
    UniProtKB/TrEMBL
    A0A8I6A1S5, A6K0P7
    Related
    ENSRNOP00000100766.1, ENSRNOT00000154475.1
    Conserved Domains (2) summary
    cd13381
    Location:117 → 222
    PH_Skap-hom_Skap2; Src kinase-associated phosphoprotein homolog and Skap 2 Pleckstrin homology (PH) domain
    cl17036
    Location:300 → 352
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920G0.1 GenPept UniProtKB/Swiss-Prot:Q920G0

Gene LinkOut

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