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CRYGN crystallin gamma N [ Homo sapiens (human) ]

Gene ID: 155051, updated on 23-Nov-2021

Summary

Official Symbol
CRYGNprovided by HGNC
Official Full Name
crystallin gamma Nprovided by HGNC
Primary source
HGNC:HGNC:20458
See related
Ensembl:ENSG00000127377 MIM:609603
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the crystallin family of proteins that are localized to the refractive structure of vertebrate eye lenses. The protein encoded by this gene is unique in that it has both beta and gamma crystallin protein motifs. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Biased expression in thyroid (RPKM 3.5), endometrium (RPKM 0.5) and 2 other tissues See more
Orthologs
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Genomic context

See CRYGN in Genome Data Viewer
Location:
7q36.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (151428832..151448790, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (151125918..151137899, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene negative regulator of ubiquitin like proteins 1 Neighboring gene WD repeat domain 86 Neighboring gene WDR86 antisense RNA 1 Neighboring gene microRNA 3907 Neighboring gene RNA, 7SL, cytoplasmic 76, pseudogene Neighboring gene Ras homolog, mTORC1 binding Neighboring gene eukaryotic translation termination factor 1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119042, MGC119043, MGC119044, MGC119045

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables structural constituent of eye lens IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in lens development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
gamma-crystallin N
Names
gamma-N-crystallin
gammaN-crystallin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308292.1NP_001295221.1  gamma-crystallin N isoform b

    See identical proteins and their annotated locations for NP_001295221.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks an alternate exon, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC005996, BC043605, BC100879, CN290143
    Consensus CDS
    CCDS78289.1
    UniProtKB/Swiss-Prot
    Q8WXF5
    Related
    ENSP00000420157.1, ENST00000491928.1
    Conserved Domains (1) summary
    pfam00030
    Location:788
    Crystall; Beta/Gamma crystallin
  2. NM_144727.3NP_653328.1  gamma-crystallin N isoform a

    See identical proteins and their annotated locations for NP_653328.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC005996
    Consensus CDS
    CCDS5926.1
    UniProtKB/Swiss-Prot
    Q8WXF5
    UniProtKB/TrEMBL
    A0A090N8I5
    Related
    ENSP00000338613.3, ENST00000337323.3
    Conserved Domains (2) summary
    pfam00030
    Location:788
    Crystall; Beta/Gamma crystallin
    cl02528
    Location:96136
    Crystall; Beta/Gamma crystallin

RNA

  1. NR_131779.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005996, BC043605
    Related
    ENST00000476631.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    151428832..151448790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249952.4XP_005250009.1  gamma-crystallin N isoform X1

    Related
    ENSP00000495938.1, ENST00000644350.1
    Conserved Domains (1) summary
    pfam00030
    Location:788
    Crystall; Beta/Gamma crystallin
  2. XM_017011773.1XP_016867262.1  gamma-crystallin N isoform X2

    UniProtKB/Swiss-Prot
    Q8WXF5
    Conserved Domains (1) summary
    pfam00030
    Location:788
    Crystall; Beta/Gamma crystallin

RNA

  1. XR_002956412.1 RNA Sequence

  2. XR_002956411.1 RNA Sequence

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