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Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 [ Mus musculus (house mouse) ]

Gene ID: 15490, updated on 1-Mar-2024

Summary

Official Symbol
Hsd17b7provided by MGI
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 7provided by MGI
Primary source
MGI:MGI:1330808
See related
Ensembl:ENSMUSG00000026675 AllianceGenome:MGI:1330808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ERG27
Summary
Enables 3-keto sterol reductase activity; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity; and estradiol 17-beta-dehydrogenase activity. Involved in animal organ development and cellular hormone metabolic process. Acts upstream of or within several processes, including cholesterol biosynthetic process; embryonic skeletal system development; and nervous system development. Located in endoplasmic reticulum membrane. Is expressed in several structures, including autopod; branchial arch; eye; nervous system; and spleen primordium. Orthologous to human HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 11.9), ovary adult (RPKM 10.5) and 27 other tissues See more
Orthologs
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Genomic context

See Hsd17b7 in Genome Data Viewer
Location:
1 H3; 1 76.84 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (169777109..169796757, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (169949535..169969242, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22114 Neighboring gene coiled-coil domain containing 190 Neighboring gene RIKEN cDNA 3110045C21 gene Neighboring gene STARR-positive B cell enhancer ABC_E501 Neighboring gene discoidin domain receptor family, member 2 Neighboring gene STARR-seq mESC enhancer starr_02981 Neighboring gene STARR-seq mESC enhancer starr_02982 Neighboring gene STARR-seq mESC enhancer starr_02983 Neighboring gene STARR-seq mESC enhancer starr_02984 Neighboring gene STARR-seq mESC enhancer starr_02986 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
Names
17-beta-HSD 7
17-beta-hydroxysteroid dehydrogenase 7
3-keto-steroid reductase
dihydrotestosterone oxidoreductase
estradiol 17-beta-dehydrogenase 7
NP_001407165.1
NP_001407166.1
NP_001407167.1
NP_034606.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420236.1NP_001407165.1  3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC139673
    UniProtKB/TrEMBL
    Q8C5N9
  2. NM_001420237.1NP_001407166.1  3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC139673
  3. NM_001420238.1NP_001407167.1  3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC139673
  4. NM_010476.4NP_034606.3  3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 isoform 2

    See identical proteins and their annotated locations for NP_034606.3

    Status: VALIDATED

    Source sequence(s)
    AC139673
    Consensus CDS
    CCDS35766.1
    UniProtKB/Swiss-Prot
    O88736, Q8K5C9, Q921L1
    Related
    ENSMUSP00000027989.7, ENSMUST00000027989.13
    Conserved Domains (2) summary
    cd08941
    Location:2280
    3KS_SDR_c; 3-keto steroid reductase, classical (c) SDRs
    COG1028
    Location:1305
    FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    169777109..169796757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)