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Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 [ Mus musculus (house mouse) ]

Gene ID: 15485, updated on 5-Jan-2023

Summary

Official Symbol
Hsd17b1provided by MGI
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 1provided by MGI
Primary source
MGI:MGI:105077
See related
Ensembl:ENSMUSG00000019301 AllianceGenome:MGI:105077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E2DH; 17HSDB1; Hsd17ba; 17beta-HSD
Summary
Enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity and testosterone dehydrogenase [NAD(P)] activity. Involved in estrogen biosynthetic process and testosterone biosynthetic process. Predicted to be located in cytosol. Is expressed in several structures, including adrenal gland; genitourinary system; spleen; submandibular gland; and trachea. Orthologous to human HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward ovary adult (RPKM 78.1) See more
Orthologs
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Genomic context

See Hsd17b1 in Genome Data Viewer
Location:
11 D; 11 64.17 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100968792..100972014)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101077968..101081188)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit A1 Neighboring gene microRNA 6928 Neighboring gene alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) Neighboring gene Coenzyme A synthase Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein Neighboring gene MAX-like protein X

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NADP binding ISO
Inferred from Sequence Orthology
more info
 
enables NADP+ binding ISO
Inferred from Sequence Orthology
more info
 
enables dihydrotestosterone 17-beta-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables estradiol 17-beta-dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables estradiol 17-beta-dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables estradiol 17-beta-dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables estradiol binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid binding ISO
Inferred from Sequence Orthology
more info
 
enables testosterone dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
enables testosterone dehydrogenase [NAD(P)] activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
17-beta-hydroxysteroid dehydrogenase type 1; estradiol 17-beta-dehydrogenase 1
Names
17-beta-HSD 1
NP_034605.1
XP_006532360.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010475.2NP_034605.1  17-beta-hydroxysteroid dehydrogenase type 1

    See identical proteins and their annotated locations for NP_034605.1

    Status: VALIDATED

    Source sequence(s)
    BE691221, X89627
    Consensus CDS
    CCDS25445.1
    UniProtKB/Swiss-Prot
    P51656
    UniProtKB/TrEMBL
    Q790P4
    Related
    ENSMUSP00000019445.6, ENSMUST00000019445.6
    Conserved Domains (2) summary
    pfam00106
    Location:5192
    adh_short; short chain dehydrogenase
    cl21454
    Location:4260
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100968792..100972014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532297.3XP_006532360.1  estradiol 17-beta-dehydrogenase 1 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:4200
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins