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Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 [ Mus musculus (house mouse) ]

Gene ID: 15483, updated on 30-Mar-2023

Summary

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Official Symbol
Hsd11b1provided by MGI
Official Full Name
hydroxysteroid 11-beta dehydrogenase 1provided by MGI
Primary source
MGI:MGI:103562
See related
Ensembl:ENSMUSG00000016194 AllianceGenome:MGI:103562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity. Acts upstream of or within lung development. Predicted to be located in apical part of cell; nuclear membrane; and rough endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study cortisone reductase deficiency 2. Human ortholog(s) of this gene implicated in cortisone reductase deficiency; cortisone reductase deficiency 2; and obesity. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 236.8), lung adult (RPKM 66.7) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Hsd11b1 in Genome Data Viewer
Location:
1; 1 H6
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (192903948..192946353, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (193221640..193264045, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A130010J15 gene Neighboring gene interferon regulatory factor 6 Neighboring gene TRAF3 interacting protein 3 Neighboring gene G0/G1 switch gene 2 Neighboring gene laminin, beta 3 Neighboring gene predicted gene, 51741

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice. Akalestou E, et al. Front Endocrinol (Lausanne), 2022. PMID 36246869, Free PMC Article
  2. 11β-HSD1 contributes to age-related metabolic decline in male mice. Morgan SA, et al. J Endocrinol, 2022 Dec 1. PMID 36205523, Free PMC Article
  3. The GR-gp78 Pathway is involved in Hepatic Lipid Accumulation Induced by Overexpression of 11β-HSD1. Hu M, et al. Int J Biol Sci, 2022. PMID 35637957, Free PMC Article
  4. Enhanced Angiogenesis by 11βHSD1 Blockage Is Insufficient to Improve Reperfusion Following Hindlimb Ischaemia. Wu J, et al. Front Cardiovasc Med, 2021. PMID 35097015, Free PMC Article
  5. Transient expansion of the expression region of Hsd11b1, encoding 11β-hydroxysteroid dehydrogenase type 1, in the developing mouse neocortex. Doi M, et al. J Neurochem, 2021 Nov. PMID 34490902

See all (169) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 11beta-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD.
    Title: 11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD.
  2. 11beta-HSD1 contributes to age-related metabolic decline in male mice.
    Title: 11β-HSD1 contributes to age-related metabolic decline in male mice.
  3. The GR-gp78 Pathway is involved in Hepatic Lipid Accumulation Induced by Overexpression of 11beta-HSD1.
    Title: The GR-gp78 Pathway is involved in Hepatic Lipid Accumulation Induced by Overexpression of 11β-HSD1.
  4. Transient expansion of the expression region of Hsd11b1, encoding 11beta-hydroxysteroid dehydrogenase type 1, in the developing mouse neocortex.
    Title: Transient expansion of the expression region of Hsd11b1, encoding 11β-hydroxysteroid dehydrogenase type 1, in the developing mouse neocortex.
  5. Increased Expression of 11beta-Hydroxysteroid Dehydrogenase Type 1 Contributes to Epidermal Permeability Barrier Dysfunction in Aged Skin.
    Title: Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 Contributes to Epidermal Permeability Barrier Dysfunction in Aged Skin.
  6. The formation of 7-keto,25-hydroxycholesterol from 7-ketocholesterol by cholesterol 25-hydroxylase (CH25H) and further stereospecific oxoreduction to 7beta,25-dihydroxycholesterol by human and mouse 11-beta-HSD1 could be demonstrated.
    Title: Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2.
  7. tis study shows that 11 beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis
    Title: 11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis.
  8. These data suggest that 11beta-HSD1 is not crucial for survival of experimental malaria, but alters its progression in a parasite strain-specific manner.
    Title: 11β-hydroxysteroid dehydrogenase type 1 has no effect on survival during experimental malaria but affects parasitemia in a parasite strain-specific manner.
  9. exercise training increases pulmonary expression of 11beta-HSD1, thus contributing to local glucocorticoid activation and suppression of pulmonary inflammation in obese mice
    Title: In obese mice, exercise training increases 11β-HSD1 expression, contributing to glucocorticoid activation and suppression of pulmonary inflammation.
  10. study demonstrates that glucocorticoid-induced insulin resistance was dependent on 11beta-HSD1, resulting in the critical activation of JNK signaling in adipocytes.
    Title: 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes.
Submit: New GeneRIF Correction See all GeneRIFs (98)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables 7-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding ISO
Inferred from Sequence Orthology
more info
  
enables cortisol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables steroid binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables steroid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glucocorticoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glucocorticoid catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mineralocorticoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
11-beta-hydroxysteroid dehydrogenase 1; corticosteroid 11-beta-dehydrogenase isozyme 1
Names
11-DH
11-beta-HSD1
11-beta-HSD1A/MCR
11-beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase
11beta-HSD-1
11beta-HSD1A
11beta-hydroxysteroid dehydrogenase type 1
7-oxosteroid reductase
Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta-HSD1A)
liver-type 11-beta-HSD
NP_001038216.1
NP_032314.2
XP_006497291.1
XP_030105692.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044751.1 → NP_001038216.1  11-beta-hydroxysteroid dehydrogenase 1

    See identical proteins and their annotated locations for NP_001038216.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. An in-frame AUG is located 41 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
    Source sequence(s)
    AI099306, AI132676, AK149518
    Consensus CDS
    CCDS15635.1
    UniProtKB/Swiss-Prot
    P50172
    UniProtKB/TrEMBL
    Q4JHD9
    Related
    ENSMUSP00000016338.9, ENSMUST00000016338.15
    Conserved Domains (1) summary
    cd05332
    Location:32 → 279
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  2. NM_008288.2 → NP_032314.2  11-beta-hydroxysteroid dehydrogenase 1

    See identical proteins and their annotated locations for NP_032314.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. An in-frame AUG is located 41 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
    Source sequence(s)
    AI132676, AI182353, DQ089001
    Consensus CDS
    CCDS15635.1
    UniProtKB/Swiss-Prot
    P50172
    UniProtKB/TrEMBL
    Q4JHD9
    Related
    ENSMUSP00000125620.2, ENSMUST00000161737.8
    Conserved Domains (1) summary
    cd05332
    Location:32 → 279
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    192903948..192946353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249832.1 → XP_030105692.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2

    UniProtKB/Swiss-Prot
    P50172
    UniProtKB/TrEMBL
    Q4JHD9
    Conserved Domains (1) summary
    cd05332
    Location:32 → 279
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  2. XM_006497228.3 → XP_006497291.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

    Conserved Domains (1) summary
    cd05332
    Location:44 → 291
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50172.3 GenPept UniProtKB/Swiss-Prot:P50172

Gene LinkOut

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