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SLC2A12 solute carrier family 2 member 12 [ Homo sapiens (human) ]

Gene ID: 154091, updated on 8-Jul-2021

Summary

Official Symbol
SLC2A12provided by HGNC
Official Full Name
solute carrier family 2 member 12provided by HGNC
Primary source
HGNC:HGNC:18067
See related
Ensembl:ENSG00000146411 MIM:610372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUT8; GLUT12
Summary
SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in prostate (RPKM 9.5), endometrium (RPKM 4.6) and 18 other tissues See more
Orthologs
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Genomic context

See SLC2A12 in Genome Data Viewer
Location:
6q23.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (133987581..134052651, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (134308719..134373762, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TCF21 antisense RNA inducing promoter demethylation Neighboring gene long intergenic non-protein coding RNA 1312 Neighboring gene transcription factor 21 Neighboring gene epithelial splicing regulatory protein 1 pseudogene Neighboring gene TATA-box binding protein like 1 Neighboring gene RNA, 7SL, cytoplasmic 408, pseudogene Neighboring gene high mobility group AT-hook 1 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in hexose transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 12
Names
GLUT-12
glucose transporter type 12
solute carrier family 2 (facilitated glucose transporter), member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145176.3NP_660159.1  solute carrier family 2, facilitated glucose transporter member 12

    See identical proteins and their annotated locations for NP_660159.1

    Status: VALIDATED

    Source sequence(s)
    AL035699, AL833602, AY046419, DB253903
    Consensus CDS
    CCDS5169.1
    UniProtKB/Swiss-Prot
    Q8TD20
    Related
    ENSP00000275230.5, ENST00000275230.6
    Conserved Domains (1) summary
    pfam00083
    Location:44561
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    133987581..134052651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010311.2XP_016865800.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X2

  2. XM_006715349.4XP_006715412.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X1

    Conserved Domains (2) summary
    cd06174
    Location:45363
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG0477
    Location:43371
    ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]
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