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Hoxa7 homeobox A7 [ Mus musculus (house mouse) ]

Gene ID: 15404, updated on 5-Jan-2023

Summary

Official Symbol
Hoxa7provided by MGI
Official Full Name
homeobox A7provided by MGI
Primary source
MGI:MGI:96179
See related
Ensembl:ENSMUSG00000038236 AllianceGenome:MGI:96179
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M6; Hox-1.1
Summary
Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within several processes, including embryonic skeletal system morphogenesis; regulation of transcription by RNA polymerase II; and stem cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; gut; and musculoskeletal system. Orthologous to human HOXA7 (homeobox A7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 14.9), kidney adult (RPKM 6.2) and 9 other tissues See more
Orthologs
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Genomic context

See Hoxa7 in Genome Data Viewer
Location:
6 B3; 6 25.4 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (52192603..52195553, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (52215623..52218573, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene homeobox A3 Neighboring gene Hoxa cluster antisense RNA 3 Neighboring gene homeobox A6 Neighboring gene mistral long non-coding RNA Neighboring gene homeobox A9 Neighboring gene predicted gene, 52902 Neighboring gene microRNA 196b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within stem cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein Hox-A7
Names
HOMEOBOX PROTEIN HOX-A7 (HOX-1.1) (M6-12) (M6)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010455.2NP_034585.1  homeobox protein Hox-A7

    See identical proteins and their annotated locations for NP_034585.1

    Status: PROVISIONAL

    Source sequence(s)
    AC015583
    Consensus CDS
    CCDS20145.1
    UniProtKB/Swiss-Prot
    P02830, Q544P0
    UniProtKB/TrEMBL
    A0A8C6GSU0
    Related
    ENSMUSP00000048648.7, ENSMUST00000048715.9
    Conserved Domains (1) summary
    pfam00046
    Location:133185
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    52192603..52195553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)