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CYLC1 cylicin 1 [ Homo sapiens (human) ]

Gene ID: 1538, updated on 1-Jun-2020

Summary

Official Symbol
CYLC1provided by HGNC
Official Full Name
cylicin 1provided by HGNC
Primary source
HGNC:HGNC:2582
See related
Ensembl:ENSG00000183035 MIM:300768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYCL1
Summary
This gene encodes a sperm head cytoskeletal protein. The encoded protein is associated with the calyx of spermatozoa and spermatids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Expression
Restricted expression toward testis (RPKM 13.2) See more
Orthologs

Genomic context

See CYLC1 in Genome Data Viewer
Location:
Xq21.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (83861126..83886700)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (83116134..83141708)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene POMP pseudogene 1 Neighboring gene TERF1 pseudogene 4 Neighboring gene ribosomal protein S6 kinase A6 Neighboring gene microRNA 548i-4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
acrosomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acrosomal matrix IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeletal calyx IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
cylicin-1
Names
cylicin I
cylicin, basic protein of sperm head cytoskeleton 1
multiple-band polypeptide I

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271680.1NP_001258609.1  cylicin-1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks an alternate in-frame exon compared to variant 1. It encodes a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AL627233, BX110674, DB028115
    Consensus CDS
    CCDS75998.1
    UniProtKB/TrEMBL
    A0A087WXC8
    Related
    ENSP00000480907.1, ENST00000621735.4
    Conserved Domains (1) summary
    pfam15241
    Location:757
    Cylicin_N; Cylicin N-terminus
  2. NM_021118.3NP_066941.1  cylicin-1 isoform 1

    See identical proteins and their annotated locations for NP_066941.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC058019, BC126461, BX110674, Z22780
    Consensus CDS
    CCDS35341.1
    UniProtKB/Swiss-Prot
    P35663
    UniProtKB/TrEMBL
    Q6PEK4
    Related
    ENSP00000331556.4, ENST00000329312.5
    Conserved Domains (1) summary
    pfam15241
    Location:8114
    Cylicin_N; Cylicin N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    83861126..83886700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262086.4XP_005262143.1  cylicin-1 isoform X1

    Conserved Domains (1) summary
    pfam15241
    Location:7113
    Cylicin_N; Cylicin N-terminus
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