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GARIN3 golgi associated RAB2 interactor family member 3 [ Homo sapiens (human) ]

Gene ID: 153745, updated on 9-Jun-2025
Official Symbol
GARIN3provided by HGNC
Official Full Name
golgi associated RAB2 interactor family member 3provided by HGNC
Primary source
HGNC:HGNC:28397
See related
Ensembl:ENSG00000170613 MIM:619883; AllianceGenome:HGNC:28397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM71B; GARI-L3
Summary
Predicted to act upstream of or within several processes, including acrosome assembly; binding activity of sperm to zona pellucida; and penetration of zona pellucida. Located in nucleus. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Restricted expression toward testis (RPKM 18.4) See more
Orthologs
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See GARIN3 in Genome Data Viewer
Location:
5q33.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (157161846..157166264, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (157680788..157685206, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (156588857..156593275, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23497 Neighboring gene hepatitis A virus cellular receptor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23499 Neighboring gene mediator complex subunit 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23503 Neighboring gene IL2 inducible T cell kinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23505 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:156713648-156714148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:156714149-156714649 Neighboring gene cytoplasmic FMR1 interacting protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16558 Neighboring gene fibronectin type III domain containing 9

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Clone Names

  • MGC26988

Gene Ontology Provided by GOA

Process Evidence Code Pubs
acts_upstream_of_or_within acrosome assembly IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within penetration of zona pellucida IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within single fertilization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatid development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in sperm head IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
Golgi-associated RAB2 interactor protein 3
Names
Golgi associated RAB2 interactor protein 3
family with sequence similarity 71 member B
golgi associated RAB2B interactor family member 3
protein FAM71B
testicular tissue protein Li 68

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130899.3NP_570969.2  Golgi-associated RAB2 interactor protein 3

    See identical proteins and their annotated locations for NP_570969.2

    Status: VALIDATED

    Source sequence(s)
    AC010609, BC025409
    Consensus CDS
    CCDS4335.1
    UniProtKB/Swiss-Prot
    Q1EDD9, Q8TC56, Q8TC64, Q96LY8
    UniProtKB/TrEMBL
    A0A140VJJ4
    Related
    ENSP00000305596.4, ENST00000302938.4
    Conserved Domains (2) summary
    pfam12480
    Location:113186
    DUF3699; Protein of unknown function (DUF3699)
    cl01503
    Location:225334
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    157161846..157166264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    157680788..157685206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)