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Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 [ Mus musculus (house mouse) ]

Gene ID: 15360, updated on 1-Mar-2024

Summary

Official Symbol
Hmgcs2provided by MGI
Official Full Name
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2provided by MGI
Primary source
MGI:MGI:101939
See related
Ensembl:ENSMUSG00000027875 AllianceGenome:MGI:101939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mHS; 1300002P16
Summary
Enables hydroxymethylglutaryl-CoA synthase activity. Predicted to be involved in acetyl-CoA metabolic process; farnesyl diphosphate biosynthetic process, mevalonate pathway; and ketone body biosynthetic process. Predicted to act upstream of or within cholesterol biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; facial bone primordium; nervous system; and reproductive system. Orthologous to human HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 447.3), liver adult (RPKM 391.9) and 3 other tissues See more
Orthologs
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Genomic context

See Hmgcs2 in Genome Data Viewer
Location:
3 F2.2; 3 42.74 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (98187747..98218054)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98280431..98310738)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40104 Neighboring gene regenerating islet-derived family, member 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:98084906-98085107 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:98085228-98085429 Neighboring gene 3-phosphoglycerate dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E4565 Neighboring gene STARR-positive B cell enhancer ABC_E11203 Neighboring gene STARR-positive B cell enhancer ABC_E7932 Neighboring gene predicted gene, 31420

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydroxymethylglutaryl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydroxymethylglutaryl-CoA synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydroxymethylglutaryl-CoA synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hydroxymethylglutaryl-CoA synthase, mitochondrial
Names
3-hydroxy-3-methylglutaryl coenzyme A synthase
HMG-CoA synthase
NP_032282.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008256.4NP_032282.2  hydroxymethylglutaryl-CoA synthase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_032282.2

    Status: VALIDATED

    Source sequence(s)
    AC121771, AC147476, AK004865
    Consensus CDS
    CCDS17662.1
    UniProtKB/Swiss-Prot
    P54869, Q64740, Q9DBK1, Q9DBM4
    UniProtKB/TrEMBL
    Q8N7N8
    Related
    ENSMUSP00000088249.3, ENSMUST00000090746.3
    Conserved Domains (3) summary
    TIGR01833
    Location:50505
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    pfam01154
    Location:53223
    HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal
    pfam08540
    Location:224505
    HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    98187747..98218054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)