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Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [ Mus musculus (house mouse) ]

Gene ID: 15357, updated on 26-Sep-2022

Summary

Official Symbol
Hmgcrprovided by MGI
Official Full Name
3-hydroxy-3-methylglutaryl-Coenzyme A reductaseprovided by MGI
Primary source
MGI:MGI:96159
See related
Ensembl:ENSMUSG00000021670 AllianceGenome:MGI:96159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Red; HMG-CoAR
Summary
Enables hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in negative regulation of amyloid-beta clearance; negative regulation of protein catabolic process; and negative regulation of protein secretion. Acts upstream of or within cholesterol biosynthetic process; negative regulation of MAP kinase activity; and visual learning. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in several structures, including autopod; branchial arch; central nervous system; forelimb bud; and ganglia. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 39.9), CNS E11.5 (RPKM 30.5) and 25 other tissues See more
Orthologs
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Genomic context

See Hmgcr in Genome Data Viewer
Location:
13 D1; 13 50.65 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (96785470..96807444, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (96648962..96670936, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene polymerase (DNA directed), kappa Neighboring gene ceramide transporter 1 Neighboring gene predicted gene, 46436 Neighboring gene predicted gene, 33171 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ankyrin repeat domain 31

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC103269

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
 
enables coenzyme A binding ISO
Inferred from Sequence Orthology
more info
 
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in coenzyme A metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in isoprenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of MAP kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of amyloid-beta clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of striated muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquinone metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within visual learning IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Names
3-hydroxy-3-methylglutaryl-CoA reductase
HMG-CoA reductase
NP_001347094.1
NP_001347095.1
NP_032281.2
XP_036013747.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360165.1NP_001347094.1  3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154851
    Consensus CDS
    CCDS26706.1
    UniProtKB/Swiss-Prot
    Q5U4I2
    Conserved Domains (1) summary
    TIGR00920
    Location:1887
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
  2. NM_001360166.1NP_001347095.1  3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154851
    Conserved Domains (1) summary
    TIGR00920
    Location:11897
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
  3. NM_008255.2NP_032281.2  3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1

    See identical proteins and their annotated locations for NP_032281.2

    Status: VALIDATED

    Source sequence(s)
    AC154851, AK048784, AK079302, AK159899, BM899288, BY124492
    Consensus CDS
    CCDS26706.1
    UniProtKB/Swiss-Prot
    Q01237, Q5U4I2
    UniProtKB/TrEMBL
    Q8BV96
    Related
    ENSMUSP00000022176.9, ENSMUST00000022176.15
    Conserved Domains (1) summary
    TIGR00920
    Location:1887
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    96785470..96807444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157854.1XP_036013747.1  3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform X1

    UniProtKB/Swiss-Prot
    Q5U4I2
    Conserved Domains (1) summary
    TIGR00920
    Location:1887
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase