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Hmgn2 high mobility group nucleosomal binding domain 2 [ Mus musculus (house mouse) ]

Gene ID: 15331, updated on 28-Dec-2022

Summary

Official Symbol
Hmgn2provided by MGI
Official Full Name
high mobility group nucleosomal binding domain 2provided by MGI
Primary source
MGI:MGI:96136
See related
Ensembl:ENSMUSG00000003038 AllianceGenome:MGI:96136
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hmg17; HMG-17
Summary
Predicted to enable chromatin binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of development, heterochronic. Located in nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; heart; and lung. Used to study Axenfeld-Rieger syndrome type 1. Orthologous to human HMGN2 (high mobility group nucleosomal binding domain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 375.6), limb E14.5 (RPKM 204.2) and 12 other tissues See more
Orthologs
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Genomic context

See Hmgn2 in Genome Data Viewer
Location:
4 D2.3; 4 66.47 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133692050..133695302, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133964739..133967991, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase polypeptide 1 Neighboring gene predicted gene 12977 Neighboring gene predicted gene, 22523 Neighboring gene dehydrodolichyl diphosphate synthase Neighboring gene lin-28 homolog A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102472, MGC103137, MGC103384, MGC118420

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in female germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
non-histone chromosomal protein HMG-17
Names
high mobility group nucleosome-binding domain-containing protein 2
high mobility group protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016957.3NP_058653.1  non-histone chromosomal protein HMG-17

    See identical proteins and their annotated locations for NP_058653.1

    Status: VALIDATED

    Source sequence(s)
    AK146999, BC090836, CJ053675
    Consensus CDS
    CCDS18759.1
    UniProtKB/Swiss-Prot
    P09602
    UniProtKB/TrEMBL
    A0A6P5PGA5, Q5BL14
    Related
    ENSMUSP00000099613.5, ENSMUST00000102553.11
    Conserved Domains (1) summary
    pfam01101
    Location:188
    HMG14_17; HMG14 and HMG17

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    133692050..133695302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)