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THAP6 THAP domain containing 6 [ Homo sapiens (human) ]

Gene ID: 152815, updated on 11-Jun-2021

Summary

Official Symbol
THAP6provided by HGNC
Official Full Name
THAP domain containing 6provided by HGNC
Primary source
HGNC:HGNC:23189
See related
Ensembl:ENSG00000174796 MIM:612535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 3.8), thyroid (RPKM 3.0) and 25 other tissues See more
Orthologs
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Genomic context

See THAP6 in Genome Data Viewer
Location:
4q21.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (75513944..75547328)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76439683..76472538)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2483 Neighboring gene uncharacterized LOC107986230 Neighboring gene ring finger and CHY zinc finger domain containing 1 Neighboring gene odontogenesis associated phosphoprotein Neighboring gene cytochrome c oxidase subunit 6C pseudogene 9 Neighboring gene cyclin dependent kinase like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC30052

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
THAP domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317791.2NP_001304720.1  THAP domain-containing protein 6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter, but has the same N- and C- termini as isoform 1.
    Source sequence(s)
    AC096759, AI743405, BX647579
    Consensus CDS
    CCDS82932.1
    UniProtKB/Swiss-Prot
    Q8TBB0
    Related
    ENSP00000370217.3, ENST00000380837.7
    Conserved Domains (1) summary
    smart00980
    Location:490
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
  2. NM_144721.6NP_653322.1  THAP domain-containing protein 6 isoform 1

    See identical proteins and their annotated locations for NP_653322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC096759, AI743405, AL833350, DC308535
    Consensus CDS
    CCDS3568.1
    UniProtKB/Swiss-Prot
    Q8TBB0
    UniProtKB/TrEMBL
    A0A024RDF9
    Related
    ENSP00000309007.3, ENST00000311638.7
    Conserved Domains (1) summary
    smart00980
    Location:490
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

RNA

  1. NR_133920.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks alternate internal exons and contains an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI445613, AK056959, BF221942

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    75513944..75547328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531667.3XP_011529969.1  THAP domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011529969.1

    UniProtKB/Swiss-Prot
    Q8TBB0
    UniProtKB/TrEMBL
    A0A024RDF9
    Conserved Domains (1) summary
    smart00980
    Location:490
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
  2. XM_011531666.2XP_011529968.1  THAP domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011529968.1

    UniProtKB/Swiss-Prot
    Q8TBB0
    UniProtKB/TrEMBL
    A0A024RDF9
    Related
    ENSP00000423720.1, ENST00000514480.1
    Conserved Domains (1) summary
    smart00980
    Location:490
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
  3. XM_005262772.3XP_005262829.1  THAP domain-containing protein 6 isoform X2

    Conserved Domains (1) summary
    smart00980
    Location:149
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
  4. XM_005262774.4XP_005262831.1  THAP domain-containing protein 6 isoform X5

    See identical proteins and their annotated locations for XP_005262831.1

    UniProtKB/Swiss-Prot
    Q8TBB0
    Related
    ENSP00000427651.1, ENST00000507556.5
    Conserved Domains (1) summary
    smart00980
    Location:490
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
  5. XM_006714109.4XP_006714172.1  THAP domain-containing protein 6 isoform X4

    Conserved Domains (1) summary
    smart00980
    Location:490
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
  6. XM_017007801.2XP_016863290.1  THAP domain-containing protein 6 isoform X6

  7. XM_017007800.1XP_016863289.1  THAP domain-containing protein 6 isoform X3

    UniProtKB/Swiss-Prot
    Q8TBB0
    Conserved Domains (1) summary
    smart00980
    Location:490
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
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