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Hhip Hedgehog-interacting protein [ Mus musculus (house mouse) ]

Gene ID: 15245, updated on 17-Jan-2023

Summary

Official Symbol
Hhipprovided by MGI
Official Full Name
Hedgehog-interacting proteinprovided by MGI
Primary source
MGI:MGI:1341847
See related
Ensembl:ENSMUSG00000064325 AllianceGenome:MGI:1341847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hhip1
Summary
Predicted to enable hedgehog family protein binding activity and zinc ion binding activity. Involved in negative regulation of smoothened signaling pathway and skeletal system morphogenesis. Acts upstream of or within several processes, including epithelial tube branching involved in lung morphogenesis; neuroblast proliferation; and regulation of fibroblast growth factor receptor signaling pathway. Located in cell surface. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human HHIP (hedgehog interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 4.5), lung adult (RPKM 2.4) and 21 other tissues See more
Orthologs
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Genomic context

See Hhip in Genome Data Viewer
Location:
8 C2; 8 37.95 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (80692479..80784691, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (79965850..80058060, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 10 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene predicted gene, 30494 Neighboring gene predicted gene, 39206 Neighboring gene Hhip1 peak 1 Gli-inducible enhancer Neighboring gene predicted gene, 53441 Neighboring gene zinc finger CCCH-type containing 15 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hedgehog family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of angiogenesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hedgehog-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020259.4NP_064655.4  hedgehog-interacting protein precursor

    See identical proteins and their annotated locations for NP_064655.4

    Status: VALIDATED

    Source sequence(s)
    AC109146, AK031841, AW121326, BC053012, BY142826, CV561558
    Consensus CDS
    CCDS22440.1
    UniProtKB/Swiss-Prot
    Q7TN16, Q9WU59
    Related
    ENSMUSP00000078047.3, ENSMUST00000079038.4
    Conserved Domains (2) summary
    pfam03024
    Location:38220
    Folate_rec; Folate receptor family
    pfam07995
    Location:226428
    GSDH; Glucose / Sorbosone dehydrogenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    80692479..80784691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530702.5XP_006530765.1  hedgehog-interacting protein isoform X1

    Conserved Domains (2) summary
    pfam03024
    Location:38220
    Folate_rec; Folate receptor family
    cl26817
    Location:226428
    GSDH; Glucose / Sorbosone dehydrogenase