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Hey2 hairy/enhancer-of-split related with YRPW motif 2 [ Mus musculus (house mouse) ]

Gene ID: 15214, updated on 27-Feb-2024

Summary

Official Symbol
Hey2provided by MGI
Official Full Name
hairy/enhancer-of-split related with YRPW motif 2provided by MGI
Primary source
MGI:MGI:1341884
See related
Ensembl:ENSMUSG00000019789 AllianceGenome:MGI:1341884
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHF1; Hrt2; Herp1; hesr2; bHLHb32
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in several processes, including circulatory system development; regulation of gene expression; and umbilical cord morphogenesis. Acts upstream of or within several processes, including cardiac muscle hypertrophy in response to stress; circulatory system development; and negative regulation of cardiac muscle cell apoptotic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study aortic valve disease and tetralogy of Fallot. Orthologous to human HEY2 (hes related family bHLH transcription factor with YRPW motif 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 30.7), frontal lobe adult (RPKM 5.4) and 12 other tissues See more
Orthologs
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Genomic context

See Hey2 in Genome Data Viewer
Location:
10 A4; 10 17.19 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (30708355..30718779, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (30832359..30842783, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8861 Neighboring gene STARR-seq mESC enhancer starr_26204 Neighboring gene nuclear encoded tRNA glutamic acid 9 (anticodon CTC) Neighboring gene predicted gene, 30618 Neighboring gene STARR-positive B cell enhancer ABC_E5124 Neighboring gene STARR-seq mESC enhancer starr_26205 Neighboring gene STARR-seq mESC enhancer starr_26206 Neighboring gene STARR-seq mESC enhancer starr_26207 Neighboring gene predicted gene, 24168 Neighboring gene VISTA enhancer mm766 Neighboring gene VISTA enhancer mm764 Neighboring gene predicted gene, 30676 Neighboring gene VISTA enhancer mm763 Neighboring gene STARR-seq mESC enhancer starr_26208

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anterior/posterior axis specification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in aortic valve morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in arterial endothelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within artery development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ascending aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrial septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within atrioventricular valve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within blood vessel endothelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cardiac epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac left ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cardiac right ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac vascular smooth muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circulatory system development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cochlea development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cochlea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within coronary vasculature morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal aorta morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within endocardial cushion to mesenchymal transition involved in heart valve formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in heart trabecula formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in labyrinthine layer blood vessel development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mesenchymal cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in muscular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of biomineral tissue development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac vascular smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pattern specification process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein-DNA complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pulmonary artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pulmonary valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of inner ear auditory receptor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of vasculogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within tricuspid valve formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tricuspid valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in umbilical cord morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ventricular cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventricular trabecula myocardium morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hairy/enhancer-of-split related with YRPW motif protein 2
Names
HES-related repressor protein 2
HESR-2
HRT-2
Hairy-E(spl)-related with YRPW motif 2
hairy and enhancer of split related 2
hairy and enhancer of split-related protein 2
hairy-related transcription factor 2
mHRT2
protein gridlock homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013904.1NP_038932.1  hairy/enhancer-of-split related with YRPW motif protein 2

    See identical proteins and their annotated locations for NP_038932.1

    Status: PROVISIONAL

    Source sequence(s)
    AF172287
    Consensus CDS
    CCDS23766.1
    UniProtKB/Swiss-Prot
    Q3TZ99, Q8CD44, Q9QUS4
    UniProtKB/TrEMBL
    Q0VGJ1
    Related
    ENSMUSP00000019924.9, ENSMUST00000019924.9
    Conserved Domains (2) summary
    smart00511
    Location:120165
    ORANGE; Orange domain
    cd00083
    Location:49105
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    30708355..30718779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)