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Hey1 hairy/enhancer-of-split related with YRPW motif 1 [ Mus musculus (house mouse) ]

Gene ID: 15213, updated on 15-Jul-2018
Official Symbol
Hey1provided by MGI
Official Full Name
hairy/enhancer-of-split related with YRPW motif 1provided by MGI
Primary source
MGI:MGI:1341800
See related
Ensembl:ENSMUSG00000040289 Vega:OTTMUSG00000051396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHF2; HRT1; Herp2; Hesr1; hesr-1; bHLHb31; AI316788; AI414254
Expression
Broad expression in lung adult (RPKM 42.5), CNS E11.5 (RPKM 13.9) and 15 other tissues See more
Orthologs
See Hey1 in Genome Data Viewer
Location:
3 A1; 3 2.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (8663359..8667038, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (8663359..8667038, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 18822 Neighboring gene predicted gene, 32496 Neighboring gene predicted gene, 32561 Neighboring gene RIKEN cDNA C230057A21 gene

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microsatellite binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microsatellite binding IDA
Inferred from Direct Assay
more info
PubMed 
microsatellite binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Notch signaling involved in heart development IC
Inferred by Curator
more info
PubMed 
Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Notch signaling pathway TAS
Traceable Author Statement
more info
PubMed 
S-shaped body morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
anterior/posterior axis specification IGI
Inferred from Genetic Interaction
more info
PubMed 
arterial endothelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
artery development IGI
Inferred from Genetic Interaction
more info
PubMed 
atrioventricular valve formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
atrioventricular valve morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
blood vessel development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
blood vessel development IGI
Inferred from Genetic Interaction
more info
PubMed 
cardiac epithelial to mesenchymal transition IGI
Inferred from Genetic Interaction
more info
PubMed 
cardiac septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
comma-shaped body morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
dorsal aorta morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
endocardial cushion morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
endocardial cushion to mesenchymal transition involved in heart valve formation IGI
Inferred from Genetic Interaction
more info
PubMed 
epithelial to mesenchymal transition involved in endocardial cushion formation IGI
Inferred from Genetic Interaction
more info
PubMed 
establishment of epithelial cell polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inner ear receptor cell stereocilium organization IGI
Inferred from Genetic Interaction
more info
PubMed 
labyrinthine layer blood vessel development IGI
Inferred from Genetic Interaction
more info
PubMed 
mesenchymal cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
osteoblast development IGI
Inferred from Genetic Interaction
more info
PubMed 
outflow tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
pulmonary valve morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of inner ear auditory receptor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of vasculogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
renal vesicle development IEP
Inferred from Expression Pattern
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
umbilical cord morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
ureteric bud morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
vasculogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
ventricular septum morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ventricular septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
ventricular trabecula myocardium morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
hairy/enhancer-of-split related with YRPW motif protein 1
Names
HRT-1
Hairy/E(spl)-related with YRPW motif 1
hairy and enhancer of split-related protein 1
hairy-related transcription factor 1
mHRT1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010423.2NP_034553.2  hairy/enhancer-of-split related with YRPW motif protein 1

    See identical proteins and their annotated locations for NP_034553.2

    Status: VALIDATED

    Source sequence(s)
    AF172286, AK140212
    Consensus CDS
    CCDS17232.1
    UniProtKB/TrEMBL
    Q9QUM5
    Related
    ENSMUSP00000038014.3, OTTMUSP00000069732, ENSMUST00000042412.4, OTTMUST00000129939
    Conserved Domains (2) summary
    smart00511
    Location:120166
    ORANGE; Orange domain
    cd00083
    Location:50107
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    8663359..8667038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530053.2XP_006530116.1  hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1

    Conserved Domains (1) summary
    smart00511
    Location:147
    ORANGE; Orange domain
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