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CPNE9 copine family member 9 [ Homo sapiens (human) ]

Gene ID: 151835, updated on 4-Jun-2020

Summary

Official Symbol
CPNE9provided by HGNC
Official Full Name
copine family member 9provided by HGNC
Primary source
HGNC:HGNC:24336
See related
Ensembl:ENSG00000144550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 3.5), skin (RPKM 0.4) and 3 other tissues See more
Orthologs

Genomic context

See CPNE9 in Genome Data Viewer
Location:
3p25.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (9703833..9729908)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9745510..9771592)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 5 pseudogene 2 Neighboring gene myotubularin related protein 14 Neighboring gene bromodomain and PHD finger containing 1 Neighboring gene 8-oxoguanine DNA glycosylase Neighboring gene calcium/calmodulin dependent protein kinase I

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dendrite extension IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
copine-9
Names
copine IX
copine family member IX
copine-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308388.2NP_001295317.1  copine-9 isoform 2

    See identical proteins and their annotated locations for NP_001295317.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 3' exon and contains an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC035735
    Consensus CDS
    CCDS77695.1
    UniProtKB/Swiss-Prot
    Q8IYJ1
    Related
    ENSP00000373342.3, ENST00000383831.7
    Conserved Domains (3) summary
    cd04047
    Location:148259
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:14135
    C2A_Copine; C2 domain first repeat in Copine
    cl00057
    Location:269492
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  2. NM_153635.3NP_705899.2  copine-9 isoform 1

    See identical proteins and their annotated locations for NP_705899.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BM545574, BU101942, BX453546, CA307982
    Consensus CDS
    CCDS2574.2
    UniProtKB/Swiss-Prot
    Q8IYJ1
    Related
    ENSP00000373343.3, ENST00000383832.8
    Conserved Domains (3) summary
    cd04047
    Location:148259
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:14135
    C2A_Copine; C2 domain first repeat in Copine
    cd01459
    Location:269525
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    9703833..9729908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005747.1XP_016861236.1  copine-9 isoform X4

  2. XM_011533386.2XP_011531688.1  copine-9 isoform X1

    Conserved Domains (3) summary
    cd04047
    Location:257368
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:132244
    C2A_Copine; C2 domain first repeat in Copine
    cd01459
    Location:378634
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
  3. XM_011533388.2XP_011531690.1  copine-9 isoform X2

    Conserved Domains (3) summary
    cd04047
    Location:257368
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:132244
    C2A_Copine; C2 domain first repeat in Copine
    cl00057
    Location:378480
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  4. XM_011533389.2XP_011531691.1  copine-9 isoform X3

    Conserved Domains (3) summary
    cd04047
    Location:257368
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:132244
    C2A_Copine; C2 domain first repeat in Copine
    cl00057
    Location:378420
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RNA

  1. XR_002959492.1 RNA Sequence

  2. XR_001740032.1 RNA Sequence

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